SIGLEC5 explained

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene.^{[1] [2]} SIGLEC5 has also been designated CD170 (cluster of differentiation 170).

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Cornish AL, Freeman S, Forbes G, etal . Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33 . Blood . 92 . 6 . 2123–32 . 1998 . 9731071 . 10.1182/blood.V92.6.2123.
• Patel N, Brinkman-Van der Linden EC, Altmann SW, etal . OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily . J. Biol. Chem. . 274 . 32 . 22729–38 . 1999 . 10428856 . 10.1074/jbc.274.32.22729 . free .
• Yousef GM, Ordon MH, Foussias G, Diamandis EP . Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes . Gene . 286 . 2 . 259–70 . 2002 . 11943481 . 10.1016/S0378-1119(02)00432-8 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Erickson-Miller CL, Freeman SD, Hopson CB, etal . Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes . Exp. Hematol. . 31 . 5 . 382–8 . 2003 . 12763136 . 10.1016/S0301-472X(03)00046-8 . free .
• Grimwood J, Gordon LA, Olsen A, etal . The DNA sequence and biology of human chromosome 19 . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Avril T, Freeman SD, Attrill H, etal . Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation . J. Biol. Chem. . 280 . 20 . 19843–51 . 2005 . 15769739 . 10.1074/jbc.M502041200 . 44764751 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Rapoport EM, Pazynina GV, Sablina MA, etal . Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides . Biochemistry Mosc. . 71 . 5 . 496–504 . 2006 . 16732727 . 10.1134/S0006297906050051 . 11537303 .
• Biedermann B, Gil D, Bowen DT, Crocker PR . Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors . Leuk. Res. . 31 . 2 . 211–20 . 2007 . 16828866 . 10.1016/j.leukres.2006.05.026 .
• Angata T, Hayakawa T, Yamanaka M, etal . Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates . FASEB J. . 20 . 12 . 1964–73 . 2006 . 17012248 . 10.1096/fj.06-5800com . free . 13740587 .
• Zhuravleva MA, Trandem K, Sun PD . J. Mol. Biol. . 375 . 2 . 437–47 . 2007 . 18022638 . 10.1016/j.jmb.2007.10.009 . 2245879 . Structural Implications of Siglec-5-Mediated Sialoglycan Recognition .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Sialic acid-binding Ig-like lectin 5 (SIGLEC5)

Notes and References

1. Kim HS . Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping . Cytogenet Cell Genet . 84 . 1–2 . 96 . Jun 1999 . 10343116 . 10.1159/000015227 . 10581090 .
2. Web site: Entrez Gene: SIGLEC5 sialic acid binding Ig-like lectin 5.