SIGLEC10 explained

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene.^{[1] [2]} Siglec-G is often referred to as the murine paralog of human Siglec-10 ^[3]

Structure and function

Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab.^[4] It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).

Gene family summary

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]

Further reading

• Li N, Zhang W, Wan T, etal . Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells . J. Biol. Chem. . 276 . 30 . 28106–12 . 2001 . 11358961 . 10.1074/jbc.M100467200 . free .
• Yousef GM, Ordon MH, Foussias G, Diamandis EP . Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants . Biochem. Biophys. Res. Commun. . 284 . 4 . 900–10 . 2001 . 11409878 . 10.1006/bbrc.2001.5053 .
• Nagano T, Yoneda T, Hatanaka Y, etal . Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone . Nat. Cell Biol. . 4 . 7 . 495–501 . 2002 . 12055638 . 10.1038/ncb808 . 4795393 .
• Kitzig F, Martinez-Barriocanal A, López-Botet M, Sayós J . Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1 . Biochem. Biophys. Res. Commun. . 296 . 2 . 355–62 . 2002 . 12163025 . 10.1016/S0006-291X(02)00885-9 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Szafranski K, Schindler S, Taudien S, etal . Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns . Genome Biol. . 8 . 8 . R154 . 2007. 17672918 . 10.1186/gb-2007-8-8-r154 . 2374985 . free .

Notes and References

1. Munday J, Kerr S, Ni J, Cornish AL, Zhang JQ, Nicoll G, Floyd H, Mattei MG, Moore P, Liu D, Crocker PR . Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor . Biochem J . 355 . Pt 2 . 489–97 . Apr 2001 . 11284738 . 1221762 . 10.1042/0264-6021:3550489 .
2. Web site: Entrez Gene: SIGLEC10 sialic acid binding Ig-like lectin 10.
3. Stanczak MA, Siddiqui SS, Trefny MP, Thommen DS, Boligan KF, von Gunten S, Tzankov A, Tietze L, Lardinois D, Heinzelmann-Schwarz V, von Bergwelt-Baildon M, Zhang W, Lenz HJ, Han Y, Amos CI, Syedbasha M, Egli A, Stenner F, Speiser DE, Varki A, Zippelius A, Läubli H . Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells . J. Clin. Invest. . 128 . Pt 11 . 4912–23 . Nov 2018 . 30130255 . 6205408 . 10.1172/JCI120612.
4. Clark, M. . A. Cooke . amp. Regulation unmasked by activation.. Nat Immunol. 14. 7 . 696–697. 2013. 10.1038/ni.2646. 23778805 . 11457712 .