SIB-1893 explained

SIB-1893 is a drug used in scientific research which was one of the first compounds developed that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR₅.^[1] It has anticonvulsant and neuroprotective effects,^[2] and reduces glutamate release.^[3] It has also been found to act as a positive allosteric modulator of mGluR₄.^[4]

Notes and References

1. Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Veliçelebi G, Johnson EC . SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5 . The Journal of Pharmacology and Experimental Therapeutics . 290 . 1 . 170–81 . July 1999 . 10381773 .
2. Chapman AG, Nanan K, Williams M, Meldrum BS . Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893) . Neuropharmacology . 39 . 9 . 1567–74 . July 2000 . 10854901 . 10.1016/S0028-3908(99)00242-7. 21528282 .
3. Wang SJ, Sihra TS . Noncompetitive metabotropic glutamate5 receptor antagonist (E)-2-methyl-6-styryl-pyridine (SIB1893) depresses glutamate release through inhibition of voltage-dependent Ca2+ entry in rat cerebrocortical nerve terminals (synaptosomes) . The Journal of Pharmacology and Experimental Therapeutics . 309 . 3 . 951–8 . June 2004 . 14982967 . 10.1124/jpet.103.064881 . 800526 .
4. Mathiesen JM, Svendsen N, Bräuner-Osborne H, Thomsen C, Ramirez MT . Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP . . 138 . 6 . 1026–30 . March 2003 . 12684257 . 1573757 . 10.1038/sj.bjp.0705159 .