| State: | CO |
| Type: | SH |
| Route: | 300 |
| Map: | Colorado State Highway 300 Map.svg |
| Map Notes: | Map of Lake County in central Colorado with SH 300 highlighted in red |
| Length Mi: | 3.356 |
| Length Ref: | [1] |
| Direction A: | West |
| Direction B: | East |
| Previous Type: | SH |
| Previous Route: | 291 |
| Next Type: | SH |
| Next Route: | 317 |
State Highway 300 (SH 300) is a 3.356miles state highway in Lake County, Colorado, United States, that connects the Leadville National Fish Hatchery with U.S. Route 24 (US 24) southeast of Leadville.
SH 300 begins at the Leadville National Fish Hatchery. From its western terminus, it actually heads very briefly west, before turning to a southerly course for about 1.1miles. The highway then runs east for the remaining 1.9miles of its route, crossing the Arkansas River just before reaching its eastern terminus. SUH 300 ends at a T intersection with US 24, southeast of Leadville. (US 24 heads north to Leadville and south to Buena Vista.)