SHROOM3 explained

Protein shroom3 also known as shroom-related protein is a protein that in humans is encoded by the SHROOM3 gene.^{[1] [2] [3]}

Protein shroom3 is a PDZ domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues.

Clinical relevance

Mutations in this gene have been shown to cause heterotaxy.^[4] A similar protein in mice is required for proper neurulation,^[3] eye,^[5] and gut development.^{[6] [7]}

Further reading

• Juriloff DM, Harris MJ . Mouse models for neural tube closure defects. . Hum. Mol. Genet. . 9 . 6 . 993–1000 . 2000 . 10767323 . 10.1093/hmg/9.6.993 . free .
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I . Proteomic identification of brain proteins that interact with dynein light chain LC8. . Proteomics . 4 . 2 . 339–46 . 2004 . 14760703 . 10.1002/pmic.200300528 . 8868600 .
• Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 7 . 2 . 143–50 . 2000 . 10819331 . 10.1093/dnares/7.2.143 . free .
• Toward a complete human genome sequence. . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097 . free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .

Notes and References

1. Hildebrand JD, Soriano P . Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice . Cell . 99 . 5 . 485–97 . 1999 . 10589677 . 10.1016/S0092-8674(00)81537-8 . 17185521 . free .
2. Hagens O, Ballabio A, Kalscheuer V, Kraehenbuhl JP, Schiaffino MV, Smith P, Staub O, Hildebrand J, Wallingford JB . A new standard nomenclature for proteins related to Apx and Shroom . BMC Cell Biol . 7 . 1. 18 . 2006 . 16615870 . 1481537 . 10.1186/1471-2121-7-18 . free .
3. Web site: Entrez Gene: SHROOM3 shroom family member 3.
4. Tariq M, Belmont JW, Lalani S, Smolarek T, Ware SM . SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing . Genome Biol. . 12 . 9 . R91 . 2011 . 21936905 . 3308054 . 10.1186/gb-2011-12-9-r91 . free .
5. Plageman TF, Chung MI, Lou M, Smith AN, Hildebrand JD, Wallingford JB, Lang RA . Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination. . Development . 137 . 3 . 405–15 . 2010 . 20081189 . 10.1242/dev.045369 . 2858910.
6. Grosse AS, Pressprich MF, Curley LB, Hamilton KL, Margolis B, Hildebrand JD, Gumucio DL . Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis. . Development . 138 . 20 . 4423–32 . 2011 . 21880782 . 10.1242/dev.065789 . 3177312.
7. Plageman TF, Zacharias AL, Gage PJ, Lang RA . Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis. . Developmental Biology . 357 . 1 . 227–34 . 2011 . 21726547 . 10.1016/j.ydbio.2011.06.027 . 3619216.