SHPRH explained

E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.^{[1] [2]}

Function

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM]SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase.^[3]

Further reading

• Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K . Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination . The Journal of Cell Biology . 175 . 5 . 703–8 . December 2006 . 17130289 . 2064669 . 10.1083/jcb.200606145 .
• Unk I, Hajdú I, Fátyol K, Szakál B, Blastyák A, Bermudez V, Hurwitz J, Prakash L, Prakash S, Haracska L . Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen . Proceedings of the National Academy of Sciences of the United States of America . 103 . 48 . 18107–12 . November 2006 . 17108083 . 1838714 . 10.1073/pnas.0608595103 . 2006PNAS..10318107U . free .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Current Biology . 14 . 16 . 1436–50 . August 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 .
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O . Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence . Nature . 377 . 6547 Suppl . 3–174 . September 1995 . 7566098 . .

Notes and References

1. Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM . Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region . Genomics . 82 . 2 . 153–61 . August 2003 . 12837266 . 10.1016/S0888-7543(03)00121-6 .
2. Web site: Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase.
3. Brühl . J . Trautwein . J . Schäfer . A . Linne . U . Bouazoune . K . The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase. . Epigenetics & Chromatin . 21 August 2019 . 12 . 1 . 52 . 10.1186/s13072-019-0294-5 . 31434570 . 6702750 . free .