SH3KBP1 explained

SH3 domain-containing kinase-binding protein 1 (synonyms - CIN85^[1] , in rodents - Ruk^[2] ) is an adaptor protein that in humans is encoded by the SH3KBP1 gene.^{[3] [4]}

Function

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM]^[5]

Interactions

SH3KBP1 has been shown to interact with B-cell linker,^[6] Grb2,^{[7] [8]} SH3GLB2,^{[9] [10]} SH3GL3,^[9] SH3GL2,^[10] BCAR1,^[6] Epidermal growth factor receptor,^{[10] [11]} CBLB,^[11] Cbl gene,^{[6] [8] [9] [10] [11]} SOS1,^[6] CRK^[6] and PAK2.^[12]

Further reading

• Salvatore P, Hanash CR, Kido Y, Imai Y, Accili D . Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN . The Journal of Biological Chemistry . 273 . 12 . 6989–97 . March 1998 . 9507006 . 10.1074/jbc.273.12.6989 . free .
• Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL . A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion . The EMBO Journal . 17 . 24 . 7320–36 . December 1998 . 9857189 . 1171078 . 10.1093/emboj/17.24.7320 .
• Take H, Watanabe S, Takeda K, Yu ZX, Iwata N, Kajigaya S . Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl . Biochemical and Biophysical Research Communications . 268 . 2 . 321–8 . February 2000 . 10679202 . 10.1006/bbrc.2000.2147 .
• Chen B, Borinstein SC, Gillis J, Sykes VW, Bogler O . The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes . The Journal of Biological Chemistry . 275 . 25 . 19275–81 . June 2000 . 10858458 . 10.1074/jbc.M908994199 . free .
• Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL . Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein . The EMBO Journal . 19 . 15 . 4015–25 . August 2000 . 10921882 . 306608 . 10.1093/emboj/19.15.4015 .
• Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S . Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes . Biochemical and Biophysical Research Communications . 278 . 1 . 167–74 . November 2000 . 11071869 . 10.1006/bbrc.2000.3760 .
• Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O . SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins . Cellular Signalling . 12 . 11–12 . 769–79 . December 2000 . 11152963 . 10.1016/S0898-6568(00)00129-7 .
• Narita T, Amano F, Yoshizaki K, Nishimoto N, Nishimura T, Tajima T, Namiki H, Taniyama T . Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in situ hybridization . Cytogenetics and Cell Genetics . 93 . 1–2 . 133–4 . 2001 . 11474197 . 10.1159/000056966 . 30342776 .
• Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I . Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors . Nature . 416 . 6877 . 183–7 . March 2002 . 11894095 . 10.1038/416183a . 2002Natur.416..183S . 635702 .
• Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S . The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met . Nature . 416 . 6877 . 187–90 . March 2002 . 11894096 . 10.1038/416187a . 2002Natur.416..187P . 4389099 .
• Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT . Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 . The Journal of Biological Chemistry . 277 . 31 . 28238–46 . August 2002 . 12029088 . 10.1074/jbc.M202783200 . free .
• Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M, Gout I . Ruk is ubiquitinated but not degraded by the proteasome . European Journal of Biochemistry . 269 . 14 . 3402–8 . July 2002 . 12135478 . 10.1046/j.1432-1033.2002.03031.x . free .
• Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I . CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases . The Journal of Biological Chemistry . 277 . 42 . 39666–72 . October 2002 . 12177062 . 10.1074/jbc.M205535200 . free .
• Haglund K, Shimokawa N, Szymkiewicz I, Dikic I . Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors . Proceedings of the National Academy of Sciences of the United States of America . 99 . 19 . 12191–6 . September 2002 . 12218189 . 129420 . 10.1073/pnas.192462299 . 2002PNAS...9912191H . free .
• Buchman VL, Luke C, Borthwick EB, Gout I, Ninkina N . Organization of the mouse Ruk locus and expression of isoforms in mouse tissues . Gene . 295 . 1 . 13–17 . July 2002 . 12242006 . 10.1016/S0378-1119(02)00821-1 .
• Tibaldi EV, Reinherz EL . CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities . International Immunology . 15 . 3 . 313–29 . March 2003 . 12618476 . 10.1093/intimm/dxg032 . free .
• Hutchings NJ, Clarkson N, Chalkley R, Barclay AN, Brown MH . Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85 . The Journal of Biological Chemistry . 278 . 25 . 22396–403 . June 2003 . 12690097 . 10.1074/jbc.M302540200 . free .

Notes and References

1. Web site: SH3KBP1 Gene - GeneCards SH3K1 Protein SH3K1 Antibody. Database. GeneCards Human Gene. www.genecards.org. 2017-12-28.
2. Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL . Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein . The EMBO Journal . 19 . 15 . 4015–25 . August 2000 . 10921882 . 10.1093/emboj/19.15.4015 . 306608 .
3. Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M . 6 . Generation and analysis of 280,000 human expressed sequence tags . Genome Research . 6 . 9 . 807–28 . September 1996 . 8889549 . 10.1101/gr.6.9.807 . free .
4. Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O . Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence . Nature . 377 . 6547 Suppl . 3–174 . September 1995 . 7566098 . .
5. Web site: Entrez Gene: SH3KBP1 SH3-domain kinase binding protein 1.
6. Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S . Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes . Biochemical and Biophysical Research Communications . 278 . 1 . 167–74 . November 2000 . 11071869 . 10.1006/bbrc.2000.3760 .
7. Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL . Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein . The EMBO Journal . 19 . 15 . 4015–25 . August 2000 . 10921882 . 306608 . 10.1093/emboj/19.15.4015 .
8. Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O . SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins . Cellular Signalling . 12 . 11–12 . 769–79 . December 2000 . 11152963 . 10.1016/S0898-6568(00)00129-7 .
9. Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S . The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met . Nature . 416 . 6877 . 187–90 . March 2002 . 11894096 . 10.1038/416187a . 2002Natur.416..187P . 4389099 .
10. Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I . Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors . Nature . 416 . 6877 . 183–7 . March 2002 . 11894095 . 10.1038/416183a . 2002Natur.416..183S . 635702 .
11. Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I . CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases . The Journal of Biological Chemistry . 277 . 42 . 39666–72 . October 2002 . 12177062 . 10.1074/jbc.M205535200 . free .
12. Kurakin AV, Wu S, Bredesen DE . Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening . The Journal of Biological Chemistry . 278 . 36 . 34102–9 . September 2003 . 12829691 . 10.1074/jbc.M305264200 . free.