SH3GL2 explained

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.^{[1] [2]}

Interactions

SH3GL2 has been shown to interact with DNM1,^{[3] [4]} Amphiphysin,^{[3] [4]} ADAM9,^[5] SH3KBP1^[6] and ADAM15.^[5]

Further reading

• Ren Y, Fang F, Davey F, Taylor M, Aiton J, Coote P, Yao J, Chen JX, Yan SD & Gunn-Moore FJ. . Endophilin I expression is increased in the brains of Alzheimer's disease patients. . Journal of Biological Chemistry . 283 . 5685–91 . 2008 . 18167351 . 9 . 10.1074/jbc.M707932200. free.
• Reutens AT . Begley CG . Endophilin-1: a multifunctional protein. . Int. J. Biochem. Cell Biol. . 34 . 10 . 1173–7 . 2002 . 12127567 . 10.1016/S1357-2725(02)00063-8 .
• So CW, Caldas C, Liu MM, etal . EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. . Proc. Natl. Acad. Sci. U.S.A. . 94 . 6 . 2563–8 . 1997 . 9122235 . 10.1073/pnas.94.6.2563 . 20128 . 1997PNAS...94.2563S . free .
• Ringstad N . Nemoto Y . De Camilli P . The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. . Proc. Natl. Acad. Sci. U.S.A. . 94 . 16 . 8569–74 . 1997 . 9238017 . 10.1073/pnas.94.16.8569 . 23017 . 1997PNAS...94.8569R . free .
• Micheva KD . Ramjaun AR . Kay BK . McPherson PS . SH3 domain-dependent interactions of endophilin with amphiphysin. . FEBS Lett. . 414 . 2 . 308–12 . 1997 . 9315708 . 10.1016/S0014-5793(97)01016-8 . 21328416 . free .
• Micheva KD . Kay BK . McPherson PS . Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin. . J. Biol. Chem. . 272 . 43 . 27239–45 . 1997 . 9341169 . 10.1074/jbc.272.43.27239 . free .
• Howard L . Nelson KK . Maciewicz RA . Blobel CP . Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. . J. Biol. Chem. . 274 . 44 . 31693–9 . 1999 . 10531379 . 10.1074/jbc.274.44.31693 . free .
• Tang Y, Hu LA, Miller WE, etal . Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. . Proc. Natl. Acad. Sci. U.S.A. . 96 . 22 . 12559–64 . 1999 . 10535961 . 10.1073/pnas.96.22.12559 . 22990 . 1999PNAS...9612559T . free .
• Cestra G, Castagnoli L, Dente L, etal . The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. . J. Biol. Chem. . 274 . 45 . 32001–7 . 1999 . 10542231 . 10.1074/jbc.274.45.32001 . free .
• So CW, So CK, Cheung N, etal . The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis. . Leukemia . 14 . 4 . 594–601 . 2000 . 10764144 . 10.1038/sj.leu.2401692 . free .
• So CW, Sham MH, Chew SL, etal . Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins. . 348 . Biochem. J. . 2. 447–58 . 2000 . 10816441 . 10.1042/0264-6021:3480447 . 1221085 .
• Zucconi A, Dente L, Santonico E, etal . Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1. . J. Mol. Biol. . 307 . 5 . 1329–39 . 2001 . 11292345 . 10.1006/jmbi.2001.4572 .
• Ramjaun AR, Angers A, Legendre-Guillemin V, etal . Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. . J. Biol. Chem. . 276 . 31 . 28913–9 . 2001 . 11384986 . 10.1074/jbc.M103198200 . free .
• Chen-Hwang MC . Chen HR . Elzinga M . Hwang YW . Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. . J. Biol. Chem. . 277 . 20 . 17597–604 . 2002 . 11877424 . 10.1074/jbc.M111101200 . free .
• Soubeyran P, Kowanetz K, Szymkiewicz I, etal . Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. . Nature . 416 . 6877 . 183–7 . 2002 . 11894095 . 10.1038/416183a . 2002Natur.416..183S . 635702 .
• Petrelli A, Gilestro GF, Lanzardo S, etal . The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. . Nature . 416 . 6877 . 187–90 . 2002 . 11894096 . 10.1038/416187a . 2002Natur.416..187P . 4389099 .
• Chatellard-Causse C, Blot B, Cristina N, etal . Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization. . J. Biol. Chem. . 277 . 32 . 29108–15 . 2002 . 12034747 . 10.1074/jbc.M204019200 . free .
• Szymkiewicz I, Kowanetz K, Soubeyran P, etal . CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. . J. Biol. Chem. . 277 . 42 . 39666–72 . 2002 . 12177062 . 10.1074/jbc.M205535200 . free .
• Haglund K . Shimokawa N . Szymkiewicz I . Dikic I . Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 19 . 12191–6 . 2002 . 12218189 . 10.1073/pnas.192462299 . 129420 . 2002PNAS...9912191H . free .
• Verstreken P, Kjaerulff O, Lloyd TE, etal . Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. . Cell . 109 . 1 . 101–12 . 2002 . 11955450 . 10.1016/S0092-8674(02)00688-8 . 11752921 . free .

Notes and References

1. Giachino C . Lantelme E . Lanzetti L . Saccone S . Bella Valle G . Migone N . A novel SH3-containing human gene family preferentially expressed in the central nervous system . Genomics . 41 . 3 . 427–34 . Jul 1997 . 9169142 . 10.1006/geno.1997.4645 .
2. Web site: Entrez Gene: SH3GL2 SH3-domain GRB2-like 2.
3. 10.1074/jbc.272.43.27239 . Micheva . K D . Kay B K . McPherson P S . Oct 1997 . Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin . J. Biol. Chem. . 272 . 43 . 27239–45 . UNITED STATES. 0021-9258. 9341169 . free .
4. Modregger . Jan . Schmidt Anne A . Ritter Brigitte . Huttner Wieland B . Plomann Markus . Feb 2003 . Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1 . J. Biol. Chem. . 278 . 6 . 4160–7 . United States. 0021-9258. 12456676 . 10.1074/jbc.M208568200 . free .
5. 10.1074/jbc.274.44.31693 . Howard . L . Nelson K K . Maciewicz R A . Blobel C P . Oct 1999 . Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1 . J. Biol. Chem. . 274 . 44 . 31693–9 . UNITED STATES. 0021-9258. 10531379 . free .
6. Soubeyran . Philippe . Kowanetz Katarzyna . Szymkiewicz Iwona . Langdon Wallace Y . Dikic Ivan . Mar 2002 . Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors . . 416 . 6877 . 183–7 . England. 0028-0836. 11894095 . 10.1038/416183a . 2002Natur.416..183S . 635702 .