SH3BP5 explained

SH3 domain-binding protein 5 is a protein that in humans is encoded by the SH3BP5 gene.^{[1] [2] [3]}

Interactions

SH3BP5 has been shown to interact with Bruton's tyrosine kinase and MAPK8.^[4]

Further reading a

• Win S, Than TA, Han D, Petrovic LM, Kaplowitz N . c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice . The Journal of Biological Chemistry . 286 . 40 . 35071–35078 . October 2011 . 21844199 . 10.1074/jbc.M111.276089 . 3186406 . free .
• Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N . Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity . Journal of Hepatology . 62 . 6 . 1367–1374 . June 2015 . 25666017 . 10.1016/j.jhep.2015.01.032 . 4439305 .
• Win S, Min RW, Zhang J, Kanel G, Wanken B, Chen Y, Li M, Wang Y, Suzuki A, Aung FW, Murray SF, Aghajan M, Than TA, Kaplowitz N . 6 . Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis . Hepatology . 74 . 6 . 3127–3145 . December 2021 . 34331779 . 10.1002/hep.32083 . 8639630 .
• Baba Y, Matsushita M, Matsuda Y, Inazawa J, Yamadori T, Hashimoto S, Kishimoto T, Tsukada S . 6 . Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding protein which preferentially associates with Bruton's tyrosine kinase, to human chromosome 1q43 and mouse chromosome 14B by in situ hybridization . Cytogenetics and Cell Genetics . 87 . 3–4 . 221–222 . 2000 . 10702676 . 10.1159/000015430 . 41425074 .
• Wiltshire C, Matsushita M, Tsukada S, Gillespie DA, May GH . A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria . The Biochemical Journal . 367 . Pt 3 . 577–585 . November 2002 . 12167088 . 1222945 . 10.1042/BJ20020553 .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . 6 . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–716 . June 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
• Court NW, Kuo I, Quigley O, Bogoyevitch MA . Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3 . Biochemical and Biophysical Research Communications . 319 . 1 . 130–137 . June 2004 . 15158451 . 10.1016/j.bbrc.2004.04.148 .
• Wiltshire C, Gillespie DA, May GH . Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein . Biochemical Society Transactions . 32 . Pt 6 . 1075–1077 . December 2004 . 15506969 . 10.1042/BST0321075 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–1292 . October 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .

Notes and References

1. Matsushita M, Yamadori T, Kato S, Takemoto Y, Inazawa J, Baba Y, Hashimoto S, Sekine S, Arai S, Kunikata T, Kurimoto M, Kishimoto T, Tsukada S . 6 . Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK) . Biochemical and Biophysical Research Communications . 245 . 2 . 337–343 . April 1998 . 9571151 . 10.1006/bbrc.1998.8420 .
2. Yamadori T, Baba Y, Matsushita M, Hashimoto S, Kurosaki M, Kurosaki T, Kishimoto T, Tsukada S . 6 . Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein . Proceedings of the National Academy of Sciences of the United States of America . 96 . 11 . 6341–6346 . May 1999 . 10339589 . 26883 . 10.1073/pnas.96.11.6341 . free . 1999PNAS...96.6341Y .
3. Web site: Entrez Gene: SH3BP5 SH3-domain binding protein 5 (BTK-associated).
4. Wiltshire C, Matsushita M, Tsukada S, Gillespie DA, May GH . A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria . The Biochemical Journal . 367 . Pt 3 . 577–585 . November 2002 . 12167088 . 1222945 . 10.1042/BJ20020553 .