SH3BP4 explained

SH3 domain-binding protein 4 is a protein that in humans is encoded by the SH3BP4 gene.^{[1] [2]}

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.

Further reading

• Wong WT, Schumacher C, Salcini AE, etal . A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. . Proc. Natl. Acad. Sci. U.S.A. . 92 . 21 . 9530–4 . 1995 . 7568168 . 10.1073/pnas.92.21.9530. 40835 . 1995PNAS...92.9530W . free .
• Salcini AE, Confalonieri S, Doria M, etal . Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. . Genes Dev. . 11 . 17 . 2239–49 . 1997 . 9303539 . 10.1101/gad.11.17.2239. 275390 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Jin J, Smith FD, Stark C, etal . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Khanobdee K, Kolberg JB, Dunlevy JR . Nuclear and plasma membrane localization of SH3BP4 in retinal pigment epithelial cells. . Mol. Vis. . 10 . 933–42 . 2005 . 15616480 .
• Benzinger A, Muster N, Koch HB, etal . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Tosoni D, Puri C, Confalonieri S, etal . TTP specifically regulates the internalization of the transferrin receptor. . Cell . 123 . 5 . 875–88 . 2006 . 16325581 . 10.1016/j.cell.2005.10.021 . 5809800 . free .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Dunlevy JR, Berryhill BL, Vergnes JP, SundarRaj N, Hassell JR . Cloning, chromosomal localization, and characterization of cDNA from a novel gene, SH3BP4, expressed by human corneal fibroblasts . Genomics . 62 . 3 . 519–24 . Mar 2000 . 10644451 . 10.1006/geno.1999.5994 .
2. Web site: Entrez Gene: SH3BP4 SH3-domain binding protein 4.