SH2D2A explained

SH2 domain-containing protein 2A is a protein that in humans is encoded by the SH2D2A gene.^{[1] [2]}

Interactions

SH2D2A has been shown to interact with MAP3K2.^[3]

Further reading

• Marti F, Lapinski PE, King PD . The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man . Immunology Letters . 97 . 2 . 165–70 . March 2005 . 15752554 . 10.1016/j.imlet.2004.10.019 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Choi YB, Kim CK, Yun Y . Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation . Journal of Immunology . 163 . 10 . 5242–9 . November 1999 . 10.4049/jimmunol.163.10.5242 . 10553045 . 12378851 .
• Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U, Sperling AI, Kozak CA, Love PE, Bluestone JA . RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation . The Journal of Experimental Medicine . 190 . 11 . 1657–68 . December 1999 . 10587356 . 2195727 . 10.1084/jem.190.11.1657 .
• Wu LW, Mayo LD, Dunbar JD, Kessler KM, Ozes ON, Warren RS, Donner DB . VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor . The Journal of Biological Chemistry . 275 . 9 . 6059–62 . March 2000 . 10692392 . 10.1074/jbc.275.9.6059 . free .
• Dai KZ, Vergnaud G, Ando A, Inoko H, Spurkland A . The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1 . Immunogenetics . 51 . 3 . 179–85 . March 2000 . 10752626 . 10.1007/s002510050029 . 37269923 .
• Smerdel A, Dai KZ, Lorentzen AR, Flatø B, Maslinski S, Thorsby E, Førre Ø, Spurkland A . Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene . Genes and Immunity . 5 . 4 . 310–2 . June 2004 . 15129233 . 10.1038/sj.gene.6364093 . 23995329 .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nature Biotechnology . 23 . 1 . 94–101 . January 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Matsumoto T, Bohman S, Dixelius J, Berge T, Dimberg A, Magnusson P, Wang L, Wikner C, Qi JH, Wernstedt C, Wu J, Bruheim S, Mugishima H, Mukhopadhyay D, Spurkland A, Claesson-Welsh L . VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis . The EMBO Journal . 24 . 13 . 2342–53 . July 2005 . 15962004 . 1173150 . 10.1038/sj.emboj.7600709 .
• Park D, Park I, Lee D, Choi YB, Lee H, Yun Y . The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration . Blood . 109 . 12 . 5122–8 . June 2007 . 17327418 . 10.1182/blood-2005-10-061838 . free .

Notes and References

1. Spurkland A, Brinchmann JE, Markussen G, Pedeutour F, Munthe E, Lea T, Vartdal F, Aasheim HC . Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites . The Journal of Biological Chemistry . 273 . 8 . 4539–46 . February 1998 . 9468509 . 10.1074/jbc.273.8.4539 . free .
2. Web site: Entrez Gene: SH2D2A SH2 domain protein 2A.
3. Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL . MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway . The Journal of Biological Chemistry . 276 . 7 . 5093–100 . February 2001 . 11073940 . 10.1074/jbc.M003719200 . free .