| State: | OK |
| Type: | SH |
| Route: | 46 |
| Map: | Ok-46 path.png |
| Maint: | ODOT |
| Length Mi: | 49.3 |
| Direction A: | South |
| Direction B: | North |
| Terminus A: | in Arnett |
| Junction: | in May |
| Terminus B: | west of Buffalo |
| Previous Type: | SH |
| Previous Route: | 45 |
| Next Type: | SH |
| Next Route: | 47 |
State Highway 46 (abbreviated SH-46) is a state highway in northwest Oklahoma. It runs 49.3miles south-to-north in Ellis and Harper Counties.
SH-46 begins at US-60/US-283/SH-51 on the west side of Arnett. The road runs north 13miles to the junction of SH-15 at Gage, then continues another 22miles to May, where it crosses US-270/US-412/SH-3.
Three miles north of May, SH-46 crosses the North Canadian River, and 4miles after that, SH-149 branches off to the west, connecting to the town of Laverne. Seven miles later, SH-46 ends at US-64, 8miles west of Buffalo.