SGSM2 explained

Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2 gene.^{[1] [2]}

Clinical relevance

In a recent genome-wide association study, this gene has been associated with fasting glucose traits, type 2 diabetes and obesity.^[3]

Further reading

• Stelzl U, Worm U, Lalowski M, etal . A human protein-protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . free . 11858/00-001M-0000-0010-8592-0 . free .
• Vasan RS, Glazer NL, Felix JF, etal . Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. . JAMA . 302 . 2 . 168–78 . 2009 . 19584346 . 10.1001/jama.2009.978-a . 2975567.
• Ishikawa K, Nagase T, Nakajima D, etal . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 4 . 5 . 307–13 . 1997 . 9455477 . 10.1093/dnares/4.5.307. free .
• Yang H . Sasaki T . Minoshima S . Shimizu N . Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. . Genomics . 90 . 2 . 249–60 . 2007 . 17509819 . 10.1016/j.ygeno.2007.03.013 . free .
• Ishibashi K . Kanno E . Itoh T . Fukuda M . Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. . Genes Cells . 14 . 1 . 41–52 . 2009 . 19077034 . 10.1111/j.1365-2443.2008.01251.x . free .

Notes and References

1. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.. H . Yang. Genomics. 2007. 90. 2. 249–260. 17509819. 10.1016/j.ygeno.2007.03.013. etal. free.
2. Web site: Entrez Gene: small G protein signaling modulator 2.
3. Strawbridge. RJ. Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes.. Diabetes. 2011-08-26. 21873549. 10.2337/db11-0415. 3178302. 60. 10. 2624–34. etal.