Shugoshin 2 Explained

Shugoshin 2 (Shugoshin-2), also known as Shugoshin-like 2, is a protein which in humans is encoded by the SGO2 gene.^{[1] [2] [3]}

Function

Shugoshin-2 is one of the two mammalian orthologs of the Shugoshin/Mei-S322 family of proteins that regulate sister chromatid cohesion by protecting the integrity of a multiprotein complex named cohesin.^[4] This protective system is essential for faithful chromosome segregation during mitosis and meiosis, which is the physical basis of Mendelian inheritance.

Further reading

• Hartley JL . Temple GF . Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Kitajima TS, Sakuno T, Ishiguro K, etal . Shugoshin collaborates with protein phosphatase 2A to protect cohesin . Nature . 441 . 7089 . 46–52 . 2006 . 16541025 . 10.1038/nature04663 . 2006Natur.441...46K . 4425074 .
• Nousiainen M, Silljé HH, Sauer G, etal . Phosphoproteome analysis of the human mitotic spindle . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . 2006PNAS..103.5391N . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Web site: UniProt . www.uniprot.org . 6 November 2022.
2. Web site: Entrez Gene: SGOL2 shugoshin-like 2 .
3. Kitajima TS . Kawashima SA . Watanabe Y . The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis . Nature . 427 . 6974 . 510–7 . February 2004 . 14730319 . 10.1038/nature02312 . 2004Natur.427..510K . 4400426 .
4. Kitajima TS . Sakuno T . Ishiguro K . Iemura S . Natsume T . Kawashima SA . Watanabe Y . Shugoshin collaborates with protein phosphatase 2A to protect cohesin . Nature . 441 . 7089 . 46–52 . May 2006 . 16541025 . 10.1038/nature04663 . 2006Natur.441...46K . 4425074 .