SFXN1 explained

Sideroflexin-1 is a protein that in humans is encoded by the SFXN1 gene.^[1] According to Nora Kory et al., SFXN1 gene product has mitochondrial serine transporter activity.^[2]

Further reading

• Kaplan RS, Mayor JA . Structure, function and regulation of the tricarboxylate transport protein from rat liver mitochondria . Journal of Bioenergetics and Biomembranes . 25 . 5 . 503–14 . October 1993 . 8132490 . 10.1007/BF01108407 . 24848406 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . November 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . 6 . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . March 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Fleming MD, Campagna DR, Haslett JN, Trenor CC, Andrews NC . A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice . Genes & Development . 15 . 6 . 652–7 . March 2001 . 11274051 . 312659 . 10.1101/gad.873001 .
• Zara V, Giudetti AM, Siculella L, Palmieri F, Gnoni GV . Covariance of tricarboxylate carrier activity and lipogenesis in liver of polyunsaturated fatty acid (n-6) fed rats . European Journal of Biochemistry . 268 . 22 . 5734–9 . November 2001 . 11722557 . 10.1046/j.0014-2956.2001.02508.x . free .
• Miyake S, Yamashita T, Taniguchi M, Tamatani M, Sato K, Tohyama M . Identification and characterization of a novel mitochondrial tricarboxylate carrier . Biochemical and Biophysical Research Communications . 295 . 2 . 463–8 . July 2002 . 12150972 . 10.1016/S0006-291X(02)00694-0 . free .
• Giudetti AM, Sabetta S, di Summa R, Leo M, Damiano F, Siculella L, Gnoni GV . Differential effects of coconut oil- and fish oil-enriched diets on tricarboxylate carrier in rat liver mitochondria . Journal of Lipid Research . 44 . 11 . 2135–41 . November 2003 . 14634051 . 10.1194/jlr.M300237-JLR200 . free .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . 6 . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nature Cell Biology . 6 . 2 . 97–105 . February 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Siculella L, Damiano F, Sabetta S, Gnoni GV . n-6 PUFAs downregulate expression of the tricarboxylate carrier in rat liver by transcriptional and posttranscriptional mechanisms . Journal of Lipid Research . 45 . 7 . 1333–40 . July 2004 . 15060089 . 10.1194/jlr.M400061-JLR200 . free .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . 6 . From ORFeome to biology: a functional genomics pipeline . Genome Research . 14 . 10B . 2136–44 . October 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Siculella L, Sabetta S, Damiano F, Giudetti AM, Gnoni GV . Different dietary fatty acids have dissimilar effects on activity and gene expression of mitochondrial tricarboxylate carrier in rat liver . FEBS Letters . 578 . 3 . 280–4 . December 2004 . 15589833 . 10.1016/j.febslet.2004.11.014 . 24071277 . free .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . 6 . The LIFEdb database in 2006 . Nucleic Acids Research . 34 . Database issue . D415-8 . January 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . 6 . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Web site: Entrez Gene: SFXN1 sideroflexin 1.
2. Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, Chan SH, Lewis CA, Wang T, Keys HR, Guo YE, Sabatini DM . 6 . SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism . Science . 362 . 6416 . eaat9528 . November 2018 . 30442778 . 6300058 . 10.1126/science.aat9528 .