SFRS9 explained

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.^[1]

Interactions

SFRS9 has been shown to interact with Y box binding protein 1^[2] and NOL3.^[3]

Further reading

• Screaton GR, Cáceres JF, Mayeda A, etal . Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. . EMBO J. . 14 . 17 . 4336–49 . 1995 . 7556075 . 10.1002/j.1460-2075.1995.tb00108.x. 394518 .
• Nayler O, Strätling W, Bourquin JP, etal . SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements. . Nucleic Acids Res. . 26 . 15 . 3542–9 . 1998 . 9671816 . 10.1093/nar/26.15.3542 . 147731 .
• Yuan Y . Li DM . Sun H . PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. . J. Biol. Chem. . 273 . 32 . 20347–53 . 1998 . 9685386 . 10.1074/jbc.273.32.20347 . free .
• Petersen-Mahrt SK, Estmer C, Ohrmalm C, etal . The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation. . EMBO J. . 18 . 4 . 1014–24 . 1999 . 10022843 . 10.1093/emboj/18.4.1014 . 1171193 .
• Stoss O . Schwaiger FW . Cooper TA . Stamm S . Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. . J. Biol. Chem. . 274 . 16 . 10951–62 . 1999 . 10196175 . 10.1074/jbc.274.16.10951 . free .
• Elliott DJ, Bourgeois CF, Klink A, etal . A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 11 . 5717–22 . 2000 . 10823932 . 10.1073/pnas.97.11.5717 . 18499 . 2000PNAS...97.5717E . free .
• Stoss O, Olbrich M, Hartmann AM, etal . The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites. . J. Biol. Chem. . 276 . 12 . 8665–73 . 2001 . 11118435 . 10.1074/jbc.M006851200 . free .
• Denegri M, Chiodi I, Corioni M, etal . Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors. . Mol. Biol. Cell . 12 . 11 . 3502–14 . 2002 . 11694584 . 10.1091/mbc.12.11.3502. 60271 .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free .
• Young PJ, DiDonato CJ, Hu D, etal . SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1. . Hum. Mol. Genet. . 11 . 5 . 577–87 . 2002 . 11875052 . 10.1093/hmg/11.5.577 . free .
• Simard MJ . Chabot B . SRp30c is a repressor of 3' splice site utilization. . Mol. Cell. Biol. . 22 . 12 . 4001–10 . 2002 . 12024014 . 10.1128/MCB.22.12.4001-4010.2002 . 133842 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Raffetseder U, Frye B, Rauen T, etal . Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. . J. Biol. Chem. . 278 . 20 . 18241–8 . 2003 . 12604611 . 10.1074/jbc.M212518200 . free .
• Xu Q . Leung DY . Kisich KO . Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils. . J. Biol. Chem. . 278 . 29 . 27112–8 . 2003 . 12738786 . 10.1074/jbc.M300824200 . free .
• Li J, Hawkins IC, Harvey CD, etal . Regulation of alternative splicing by SRrp86 and its interacting proteins. . Mol. Cell. Biol. . 23 . 21 . 7437–47 . 2003 . 14559993 . 10.1128/MCB.23.21.7437-7447.2003 . 207616 .
• Kondo S, Yamamoto N, Murakami T, etal . Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA. . Genes Cells . 9 . 2 . 121–30 . 2004 . 15009090 . 10.1111/j.1356-9597.2004.00709.x . 22248867 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wang Y, Wang J, Gao L, etal . Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1. . J. Biol. Chem. . 280 . 14 . 14230–9 . 2005 . 15695522 . 10.1074/jbc.M413846200 . free .
• Scherer SE, Muzny DM, Buhay CJ, etal . The finished DNA sequence of human chromosome 12. . Nature . 440 . 7082 . 346–51 . 2006 . 16541075 . 10.1038/nature04569 . 2006Natur.440..346S . free .

Notes and References

1. Web site: Entrez Gene: SFRS9 splicing factor, arginine/serine-rich 9.
2. Raffetseder . Ute . Frye Björn . Rauen Thomas . Jürchott Karsten . Royer Hans-Dieter . Jansen Petra Lynen . Mertens Peter R . May 2003 . Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection . J. Biol. Chem. . 278 . 20 . 18241–8 . 0021-9258. 12604611 . 10.1074/jbc.M212518200 . free .
3. 10.1074/jbc.274.16.10951 . Stoss . O . Schwaiger F W . Cooper T A . Stamm S . Apr 1999 . Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c . J. Biol. Chem. . 274 . 16 . 10951–62 . 0021-9258. 10196175 . free .