SFRS7 explained

Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in humans is encoded by the SRSF7 gene.^[1]

Function

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.^[1]

Further reading

• Popielarz M, Cavaloc Y, Mattei MG, Gattoni R, Stévenin J . The gene encoding human splicing factor 9G8. Structure, chromosomal localization, and expression of alternatively processed transcripts . The Journal of Biological Chemistry . 270 . 30 . 17830–5 . Jul 1995 . 7629084 . 10.1074/jbc.270.30.17830 . free .
• Cavaloc Y, Popielarz M, Fuchs JP, Gattoni R, Stévenin J . Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family . The EMBO Journal . 13 . 11 . 2639–49 . Jun 1994 . 8013463 . 395138 . 10.1002/j.1460-2075.1994.tb06554.x.
• Yuan Y, Li DM, Sun H . PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes . The Journal of Biological Chemistry . 273 . 32 . 20347–53 . Aug 1998 . 9685386 . 10.1074/jbc.273.32.20347 . free .
• Lejeune F, Cavaloc Y, Stevenin J . Alternative splicing of intron 3 of the serine/arginine-rich protein 9G8 gene. Identification of flanking exonic splicing enhancers and involvement of 9G8 as a trans-acting factor . The Journal of Biological Chemistry . 276 . 11 . 7850–8 . Mar 2001 . 11096110 . 10.1074/jbc.M009510200 . free .
• Nogues G, Kadener S, Cramer P, Bentley D, Kornblihtt AR . Transcriptional activators differ in their abilities to control alternative splicing . The Journal of Biological Chemistry . 277 . 45 . 43110–4 . Nov 2002 . 12221105 . 10.1074/jbc.M208418200 . free .
• Hu D, Mayeda A, Trembley JH, Lahti JM, Kidd VJ . CDK11 complexes promote pre-mRNA splicing . The Journal of Biological Chemistry . 278 . 10 . 8623–9 . Mar 2003 . 12501247 . 10.1074/jbc.M210057200 . free .
• Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG . Regulation of alternative splicing by SRrp86 and its interacting proteins . Molecular and Cellular Biology . 23 . 21 . 7437–47 . Nov 2003 . 14559993 . 207616 . 10.1128/MCB.23.21.7437-7447.2003 .
• Yang L, Li N, Wang C, Yu Y, Yuan L, Zhang M, Cao X . Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells . The Journal of Biological Chemistry . 279 . 12 . 11639–48 . Mar 2004 . 14684736 . 10.1074/jbc.M312895200 . free .
• Ropers D, Ayadi L, Gattoni R, Jacquenet S, Damier L, Branlant C, Stévenin J . Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA . The Journal of Biological Chemistry . 279 . 29 . 29963–73 . Jul 2004 . 15123677 . 10.1074/jbc.M404452200 . free .
• Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R . The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome . RNA . 10 . 6 . 929–41 . Jun 2004 . 15146077 . 1370585 . 10.1261/rna.7320604 .
• Dettwiler S, Aringhieri C, Cardinale S, Keller W, Barabino SM . Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization . The Journal of Biological Chemistry . 279 . 34 . 35788–97 . Aug 2004 . 15169763 . 10.1074/jbc.M403927200 . 39752996 . free .
• Lai MC, Tarn WY . Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins . The Journal of Biological Chemistry . 279 . 30 . 31745–9 . Jul 2004 . 15184380 . 10.1074/jbc.C400173200 . free.
• Huang Y, Yario TA, Steitz JA . A molecular link between SR protein dephosphorylation and mRNA export . Proceedings of the National Academy of Sciences of the United States of America . 101 . 26 . 9666–70 . Jun 2004 . 15210956 . 470732 . 10.1073/pnas.0403533101 . 2004PNAS..101.9666H . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Jacquenet S, Decimo D, Muriaux D, Darlix JL . Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production . Retrovirology . 2 . 33 . 2006 . 15907217 . 1180853 . 10.1186/1742-4690-2-33 . free .
• van Abel D, Hölzel DR, Jain S, Lun FM, Zheng YW, Chen EZ, Sun H, Chiu RW, Lo YM, van Dijk M, Oudejans CB . SFRS7-mediated splicing of tau exon 10 is directly regulated by STOX1A in glial cells . PLOS ONE . 6 . 7 . e21994 . 2011 . 21755018 . 3130792 . 10.1371/journal.pone.0021994 . 2011PLoSO...621994V . free .

Notes and References

1. Web site: Entrez Gene: SFRS7 splicing factor, arginine/serine-rich 7, 35kDa.