SFRS11 explained

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.^{[1] [2]}

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.

Interactions

SFRS11 has been shown to interact with U2AF2.^[3]

Further reading

• Zhang WJ . Wu JY . Functional properties of p54, a novel SR protein active in constitutive and alternative splicing . Mol. Cell. Biol. . 16 . 10 . 5400–8 . 1996 . 8816452 . 10.1128/MCB.16.10.5400. 231539 .
• Straub T, Grue P, Uhse A, etal . The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction . J. Biol. Chem. . 273 . 41 . 26261–4 . 1998 . 9756848 . 10.1074/jbc.273.41.26261 . free .
• Page-McCaw PS . Amonlirdviman K . Sharp PA . PUF60: a novel U2AF65-related splicing activity . RNA . 5 . 12 . 1548–60 . 2000 . 10606266 . 10.1017/S1355838299991938 . 1369877 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Sakashita E, Tatsumi S, Werner D, etal . Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo . Mol. Cell. Biol. . 24 . 3 . 1174–87 . 2004 . 14729963 . 10.1128/MCB.24.3.1174-1187.2004 . 321435 .
• Wu JY, Kar A, Kuo D, etal . SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy . Mol. Cell. Biol. . 26 . 18 . 6739–47 . 2006 . 16943417 . 10.1128/MCB.00739-06 . 1592875 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Chaudhary N . McMahon C . Blobel G . Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components . Proc Natl Acad Sci U S A . 88 . 18 . 8189–93 . October 1991 . 1896467 . 52472 . 10.1073/pnas.88.18.8189 . 1991PNAS...88.8189C . free .
2. Web site: Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11.
3. Zhang . W J . Wu J Y . October 1996 . Functional properties of p54, a novel SR protein active in constitutive and alternative splicing . Mol. Cell. Biol. . 16 . 10 . 5400–8 . UNITED STATES. 0270-7306. 8816452 . 231539 . 10.1128/MCB.16.10.5400.