SFRP5 explained

Secreted frizzled-related protein 5 is a protein that in humans is encoded by the SFRP5 gene.^{[1] [2]}

Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.

Further reading

• Veeck J, Geisler C, Noetzel E, etal . Epigenetic inactivation of the Secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis . Carcinogenesis . 29 . 5 . 991–998 . 2008 . 18356147 . 10.1093/carcin/bgn076 . free .
• Urakami S, Shiina H, Enokida H, etal . Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection . Clin. Cancer Res. . 12 . 7 Pt 1 . 2109–16 . 2006 . 16609023 . 10.1158/1078-0432.CCR-05-2468 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Deloukas P, Earthrowl ME, Grafham DV, etal . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Chang JT, Esumi N, Moore K, etal . Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium . Hum. Mol. Genet. . 8 . 4 . 575–83 . 1999 . 10072424 . 10.1093/hmg/8.4.575 . free .
• Hu E, Zhu Y, Fredrickson T, etal . Tissue restricted expression of two human Frzbs in preadipocytes and pancreas . Biochem. Biophys. Res. Commun. . 247 . 2 . 287–93 . 1998 . 9642118 . 10.1006/bbrc.1998.8784 .
• Rattner A, Hsieh JC, Smallwood PM, etal . A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors . Proc. Natl. Acad. Sci. U.S.A. . 94 . 7 . 2859–63 . 1997 . 9096311 . 10.1073/pnas.94.7.2859 . 20287 . 1997PNAS...94.2859R . free .

Notes and References

1. Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR . SARPs: A family of secreted apoptosis-related proteins . Proc Natl Acad Sci U S A . 94 . 25 . 13636–41 . Jan 1998 . 9391078 . 28358 . 10.1073/pnas.94.25.13636 . free .
2. Web site: Entrez Gene: SFRP5 secreted frizzled-related protein 5.