SFMBT1 explained

Scm-like with four mbt domains 1 is a protein that in humans is encoded by the SFMBT1 gene.^[1]

Function

This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012].

Further reading

• Zhang . J. . Bonasio . R. . Strino . F. . Kluger . Y. . Holloway . J. K. . Modzelewski . A. J. . Cohen . P. E. . Reinberg . D. . 10.1101/gad.210963.112 . SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors . Genes & Development . 27 . 7 . 749–766 . 2013 . 23592795 . 3639416 .
• Köttgen . A. . Albrecht . E. . Teumer . A. . Vitart . V. . Krumsiek . J. . Hundertmark . C. . Pistis . G. . Ruggiero . D. . O'Seaghdha . C. M. . Haller . T. . Yang . Q. . Tanaka . T. . Johnson . A. D. . Kutalik . Z. N. . Smith . A. V. . Shi . J. . Struchalin . M. . Middelberg . R. P. S. . Brown . M. J. . Gaffo . A. L. . Pirastu . N. . Li . G. . Hayward . C. . Zemunik . T. . Huffman . J. . Yengo . L. . Zhao . A. . M. F. . Liu . X. . Demirkan . Feitosa . J. H. . Genome-wide association analyses identify 18 new loci associated with serum urate concentrations . 10.1038/ng.2500 . Nature Genetics . 45 . 2 . 145–154 . 2012 . 23263486 . 3663712 . 29 .
• 10.2169/internalmedicine.50.4505 . Kato . T. . Sato . H. . Emi . M. . Seino . T. . Arawaka . S. . Iseki . C. . Takahashi . Y. . Wada . M. . Kawanami . T. . Segmental copy number loss of SFMBT1 gene in elderly individuals with ventriculomegaly: A community-based study . Internal Medicine (Tokyo, Japan) . 50 . 4 . 297–303 . 2011 . 21325761. free .
• Lin . S. . Shen . H. . Li . J. -L. . Tang . S. . Gu . Y. . Chen . Z. . Hu . C. . Rice . J. C. . Lu . J. . Wu . L. . 10.1074/jbc.M112.429605 . Proteomic and Functional Analyses Reveal the Role of Chromatin Reader SFMBT1 in Regulating Epigenetic Silencing and the Myogenic Gene Program . Journal of Biological Chemistry . 288 . 9 . 6238–6247 . 2013 . 23349461 . 3585059 . free .
• Wu . S. . Trievel . R. C. . Rice . J. C. . 10.1016/j.febslet.2007.06.025 . Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 . FEBS Letters . 581 . 17 . 3289–3296 . 2007 . 17599839 . 2045647 .
• Yang . H. C. . Liang . Y. J. . Chen . J. W. . Chiang . K. M. . Chung . C. M. . Ho . H. Y. . Ting . C. T. . Lin . T. H. . Sheu . S. H. . Tsai . W. C. . Chen . J. H. . Leu . H. B. . Yin . W. H. . Chiu . T. Y. . Chern . C. I. . Lin . S. J. . Tomlinson . B. . Guo . Y. . Sham . P. C. . Cherny . S. S. . Lam . T. H. . Thomas . G. N. . Pan . W. H. . Mariño-Ramírez . Leonardo . Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as Hypertension Susceptibility Genes in Han Chinese with a Genome-Wide Gene-Based Association Study . 10.1371/journal.pone.0032907 . PLOS ONE . 7 . 3 . e32907 . 2012 . 22479346 . 3315540 . 2012PLoSO...732907Y . free .
• 10.1016/S1074-7613(00)80163-6 . Morel . S. . Lévy . F. . Burlet-Schiltz . O. . Brasseur . F. . Probst-Kepper . M. . Peitrequin . A. L. . Monsarrat . B. . Van Velthoven . R. . Cerottini . J. C. . Boon . T. . Gairin . J. E. . Van Den Eynde . B. J. . Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells . Immunity . 12 . 1 . 107–117 . 2000 . 10661410. free .

Notes and References

1. Web site: Entrez Gene: Scm-like with four mbt domains 1. 2013-11-22 .