SFI1 explained

Sfi1 homolog, spindle assembly associated (yeast) is a protein that in humans is encoded by the SFI1 gene.^[1] It localizes to the centriole, and its S. pombe ortholog has been shown to be involved in spindle pole body duplication.^[2] SFI1 forms a complex with centrin 2.^[3]

Further reading

• Martinez-Sanz J, Kateb F, Assairi L, Blouquit Y, Bodenhausen G, Abergel D, Mouawad L, Craescu CT . Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex . Journal of Molecular Biology . 395 . 1 . 191–204 . January 2010 . 19857500 . 10.1016/j.jmb.2009.10.041 .
• Mayor T, Stierhof YD, Tanaka K, Fry AM, Nigg EA . The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion . The Journal of Cell Biology . 151 . 4 . 837–46 . November 2000 . 11076968 . 2169446 . 10.1083/jcb.151.4.837 .
• Petretti C, Savoian M, Montembault E, Glover DM, Prigent C, Giet R . The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation . EMBO Reports . 7 . 4 . 418–24 . April 2006 . 16462731 . 1456919 . 10.1038/sj.embor.7400639 .
• Casenghi M, Meraldi P, Weinhart U, Duncan PI, Körner R, Nigg EA . Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation . Developmental Cell . 5 . 1 . 113–25 . July 2003 . 12852856 . 10.1016/S1534-5807(03)00193-X . free .
• Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI . Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry . The EMBO Journal . 19 . 23 . 6569–81 . December 2000 . 11101529 . 305846 . 10.1093/emboj/19.23.6569 .
• Kilmartin JV . Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication . The Journal of Cell Biology . 162 . 7 . 1211–21 . September 2003 . 14504268 . 2173958 . 10.1083/jcb.200307064 .
• Hendrickx A, Beullens M, Ceulemans H, Den Abt T, Van Eynde A, Nicolaescu E, Lesage B, Bollen M . Docking motif-guided mapping of the interactome of protein phosphatase-1 . Chemistry & Biology . 16 . 4 . 365–71 . April 2009 . 19389623 . 10.1016/j.chembiol.2009.02.012 . free .
• Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y . Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex . Molecular Biology of the Cell . 13 . 9 . 3235–45 . September 2002 . 12221128 . 124155 . 10.1091/mbc.E02-02-0112 .
• Golsteyn RM, Mundt KE, Fry AM, Nigg EA . Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function . The Journal of Cell Biology . 129 . 6 . 1617–28 . June 1995 . 7790358 . 2291169 . 10.1083/jcb.129.6.1617 .
• Rüthnick D, Vitale J, Neuner A, Schiebel E . The N-terminus of Sfi1 and yeast centrin Cdc31 provide the assembly site for a new spindle pole body . J Cell Biol . 220 . 3 . March 2021 . 33523111 . 7852455 . 10.1083/jcb.202004196 .

Notes and References

1. Web site: Entrez Gene: Sfi1 homolog, spindle assembly associated (yeast). 2014-06-25 .
2. Elserafy M, Šarić M, Neuner A, Lin TC, Zhang W, Seybold C, Sivashanmugam L, Schiebel E . Molecular mechanisms that restrict yeast centrosome duplication to one event per cell cycle . Current Biology . 24 . 13 . 1456–66 . July 2014 . 24954044 . 10.1016/j.cub.2014.05.032 . free .
3. Martinez-Sanz J, Kateb F, Assairi L, Blouquit Y, Bodenhausen G, Abergel D, Mouawad L, Craescu CT . Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex . Journal of Molecular Biology . 395 . 1 . 191–204 . January 2010 . 19857500 . 10.1016/j.jmb.2009.10.041 .