Malonoben Explained

Malonoben (also known as tyrphostin A9, SF-6847, GCP5126, and AG-17) is an uncoupling agent/protonophore.[1] [2] As of 1974 when it was discovered, it was considered the most powerful agent of this type, with a potency over 1800 times that of 2,4-dinitrophenol - the prototypical uncoupling agent - and about 3 times the effectiveness of 5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide.[3]

Notes and References

  1. Unique action of a modified weakly acidic uncoupler without an acidic group, methylated SF 6847, as an inhibitor of oxidative phosphorylation with no uncoupling activity: possible identity of uncoupler binding protein . Biochimica et Biophysica Acta (BBA) - Bioenergetics. 933. 1. Terada . H. . Fukui . Y. . 1988-03-30 . 193–199 . 10.1016/0005-2728(88)90070-9 . 2894856 . Shinohara . Y. . Ju-ichi . M..
  2. On the stoichiometry between uncouplers of oxidative phosphorylation and respiratory chains. The catalytic action of SF 6847 (3,5-di-tert-butyl-4-hydroxy-benzylidenemalononitrile) . Biochimica et Biophysica Acta (BBA) - Bioenergetics. 387. 3. Terada . H. . VAN Dam . K. . 1975-06-17 . 507–518 . 10.1016/0005-2728(75)90089-4 . 1138887 .
  3. Terada. H.. November 7, 1974. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 387. 3. 519–532. 10.1016/0005-2728(75)90090-0. 237542. Some biochemical and physicochemical properties of the potent uncoupler SF 6847 (3,5-di-tert-butyl-4-hydroxybenzylidenemalononitrile).

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