Protein SET explained

Protein SET, also known as Protein SET 1, is a protein that in humans is encoded by the SET gene.^{[1] [2] [3]}

Interactions

Protein SET has been shown to interact with:

• Acidic leucine-rich nuclear phosphoprotein 32 family member A,^[4]
• CDK5R1,^[5]
• KLF5,^[6]
• NME1,^[7] and
• TAF1A.^[8]

Further reading

• Nagata K, Kawase H, Handa H, Yano K, Yamasaki M, Ishimi Y, Okuda A, Kikuchi A, Matsumoto K . Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis . Proceedings of the National Academy of Sciences of the United States of America . 92 . 10 . 4279–83 . May 1995 . 7753797 . 41927 . 10.1073/pnas.92.10.4279 . 1995PNAS...92.4279N . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Adachi Y, Pavlakis GN, Copeland TD . Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia . FEBS Letters . 340 . 3 . 231–5 . Mar 1994 . 8131851 . 10.1016/0014-5793(94)80144-4 . 36974869 . free . 1994FEBSL.340..231A .
• Vaesen M, Barnikol-Watanabe S, Götz H, Awni LA, Cole T, Zimmermann B, Kratzin HD, Hilschmann N . Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII . Biological Chemistry Hoppe-Seyler . 375 . 2 . 113–26 . Feb 1994 . 8192856 . 10.1515/bchm3.1994.375.2.113 .
• Adachi Y, Pavlakis GN, Copeland TD . Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia . The Journal of Biological Chemistry . 269 . 3 . 2258–62 . Jan 1994 . 10.1016/S0021-9258(17)42162-4 . 8294483 . free .
• Adler HT, Nallaseth FS, Walter G, Tkachuk DC . HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A . The Journal of Biological Chemistry . 272 . 45 . 28407–14 . Nov 1997 . 9353299 . 10.1074/jbc.272.45.28407 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Carlson SG, Eng E, Kim EG, Perlman EJ, Copeland TD, Ballermann BJ . Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor . Journal of the American Society of Nephrology . 9 . 10 . 1873–80 . Oct 1998 . 10.1681/ASN.V9101873 . 9773788 . free .
• Brennan CM, Gallouzi IE, Steitz JA . Protein ligands to HuR modulate its interaction with target mRNAs in vivo . The Journal of Cell Biology . 151 . 1 . 1–14 . Oct 2000 . 11018049 . 2189805 . 10.1083/jcb.151.1.1 .
• Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB . Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators . Molecular and Cellular Biology . 20 . 23 . 8933–43 . Dec 2000 . 11073993 . 86548 . 10.1128/MCB.20.23.8933-8943.2000 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . Nov 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D . Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein . Cell . 104 . 1 . 119–30 . Jan 2001 . 11163245 . 10.1016/S0092-8674(01)00196-9 . 11144887 . free .
• Minakuchi M, Kakazu N, Gorrin-Rivas MJ, Abe T, Copeland TD, Ueda K, Adachi Y . Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET . European Journal of Biochemistry . 268 . 5 . 1340–51 . Mar 2001 . 11231286 . 10.1046/j.1432-1327.2001.02000.x . free . 2433/150179 .
• Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J . Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks . The Journal of Biological Chemistry . 276 . 46 . 43285–93 . Nov 2001 . 11555662 . 10.1074/jbc.M108137200 . free .
• Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ . The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity . The Journal of Biological Chemistry . 277 . 9 . 7324–32 . Mar 2002 . 11741927 . 10.1074/jbc.M107270200 . free . 10536/DRO/DU:30101408 . free .
• Fan Z, Beresford PJ, Zhang D, Lieberman J . HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A . Molecular and Cellular Biology . 22 . 8 . 2810–20 . Apr 2002 . 11909973 . 133744 . 10.1128/MCB.22.8.2810-2820.2002 .
• Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M . The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing . The Journal of Biological Chemistry . 277 . 28 . 25026–31 . Jul 2002 . 11978794 . 10.1074/jbc.M202256200 . free .

Notes and References

1. von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G . Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene . Molecular and Cellular Biology . 12 . 8 . 3346–55 . Aug 1992 . 1630450 . 364582 . 10.1128/mcb.12.8.3346.
2. Li M, Makkinje A, Damuni Z . The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A . The Journal of Biological Chemistry . 271 . 19 . 11059–62 . May 1996 . 8626647 . 10.1074/jbc.271.19.11059 . free .
3. Web site: Entrez Gene: SET SET translocation (myeloid leukemia-associated).
4. Fan Z, Beresford PJ, Zhang D, Lieberman J . HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A . Molecular and Cellular Biology . 22 . 8 . 2810–20 . Apr 2002 . 11909973 . 133744 . 10.1128/mcb.22.8.2810-2820.2002.
5. Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ . The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity . The Journal of Biological Chemistry . 277 . 9 . 7324–32 . Mar 2002 . 11741927 . 10.1074/jbc.M107270200 . free . 10536/DRO/DU:30101408 . free .
6. Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R . Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain . Molecular and Cellular Biology . 23 . 23 . 8528–41 . Dec 2003 . 14612398 . 262669 . 10.1128/mcb.23.23.8528-8541.2003.
7. Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J . Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor . Cell . 112 . 5 . 659–72 . Mar 2003 . 12628186 . 10.1016/s0092-8674(03)00150-8. 14019153 . free .
8. Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D . Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein . Cell . 104 . 1 . 119–30 . Jan 2001 . 11163245 . 10.1016/s0092-8674(01)00196-9. 11144887 . free .