SETD3 (gene) explained

SET domain containing 3 (SETD3) is a protein that in humans is encoded by the SETD3 gene.^[1] It is a methyl transferase implicated in the replication of all enteroviruses. A mouse line deficient in SETD3 expression was shown to be immune to enterovirus infection. This could pave the way for the prevention of diseases like the common cold, myocarditis, aseptic meningitis and polio.^[2] SETD3 is capable of methylating the cytoskeletal protein actin on histidine residues.^{[3] [4]}

In patients of the Estrogen Receptor-positive, and Luminal A-type breast cancer classification, a high expression of SETD3 is associated with better relapse-free survival, whereas in patients lacking expression of estrogen-, progesterone- and HER2/neu-receptor, and those affected by a p53-mutation, SETD3 was associated with poor relapse-free survival.^[5]

Downregulation of SETD3 expression with small interfering RNA resulted in an inhibition of cytoskeletal function and invasiveness of triple-negative breast cancer cells.

See also

• Methyltransferase
• Histone methyltransferase

Further reading

• Cooper SE, Hodimont E, Green CM . A fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cells . Cell Cycle . 14 . 15 . 2509–19 . August 2015 . 26030842 . 4613188 . 10.1080/15384101.2015.1053667 .
• Pires-Luís AS, Vieira-Coimbra M, Vieira FQ, Costa-Pinheiro P, Silva-Santos R, Dias PC, Antunes L, Lobo F, Oliveira J, Gonçalves CS, Costa BM, Henrique R, Jerónimo C . 6 . Expression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication . Epigenetics . 10 . 11 . 1033–43 . 2015 . 26488939 . 4844211 . 10.1080/15592294.2015.1103578 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Actin-histidine N-methyltransferase (SETD3)

Notes and References

1. Web site: Entrez Gene: SET domain containing 3 . 2018-01-22 .
2. Diep J, Ooi YS, Wilkinson AW, Peters CE, Foy E, Johnson JR, Zengel J, Ding S, Weng KF, Laufman O, Jang G, Xu J, Young T, Verschueren E, Kobluk KJ, Elias JE, Sarnow P, Greenberg HB, Hüttenhain R, Nagamine CM, Andino R, Krogan NJ, Gozani O, Carette JE . 6 . Enterovirus pathogenesis requires the host methyltransferase SETD3 . Nature Microbiology . 4 . 12 . 2523–2537 . December 2019 . 31527793 . 6879830 . 10.1038/s41564-019-0551-1 .
3. Wilkinson AW, Diep J, Dai S, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C, Trivedi DV, Ruppel KM, Vilches-Moure JG, Casey KM, Mak J, Cowan T, Elias JE, Nagamine CM, Spudich JA, Cheng X, Carette JE, Gozani O . 6 . SETD3 is an actin histidine methyltransferase that prevents primary dystocia . Nature . 565 . 7739 . 372–376 . January 2019 . 30626964 . 6511263 . 10.1038/s41586-018-0821-8 .
4. Guo Q, Liao S, Kwiatkowski S, Tomaka W, Yu H, Wu G, Tu X, Min J, Drozak J, Xu C . 6 . Structural insights into SETD3-mediated histidine methylation on β-actin . eLife . 8 . February 2019 . 30785395 . 6400499 . 10.7554/eLife.43676 . free .
5. Hassan N, Rutsch N, Győrffy B, Espinoza-Sánchez NA, Götte M . SETD3 acts as a prognostic marker in breast cancer patients and modulates the viability and invasion of breast cancer cells . Scientific Reports . 10 . 1 . 2262 . February 2020 . 32042016 . 10.1038/s41598-020-59057-5. 7010743 . 2020NatSR..10.2262H . free .