SESN3 explained

Sestrin 3 is a protein that in humans is encoded by the SESN3 gene.^[1]

Function

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N . FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor . Dev. Cell . 18 . 4 . 592–604 . 2010 . 20412774 . 3031984 . 10.1016/j.devcel.2010.03.008 .
• Zamkova M, Khromova N, Kopnin BP, Kopnin P . Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways . Cell Cycle . 12 . 5 . 826–36 . 2013 . 23388456 . 3610730 . 10.4161/cc.23723 .
• Nascimento EB, Osler ME, Zierath JR . Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle . Am. J. Physiol. Endocrinol. Metab. . 305 . 11 . E1408–14 . 2013 . 24129397 . 3882372 . 10.1152/ajpendo.00212.2013 .
• Vakana E, Arslan AD, Szilard A, Altman JK, Platanias LC . Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells . PLOS ONE . 8 . 11 . e78780 . 2013 . 24260131 . 3832611 . 10.1371/journal.pone.0078780 . 2013PLoSO...878780V . free .
• Kang X, Petyaykina K, Tao R, Xiong X, Dong XC, Liangpunsakul S . The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury . Am. J. Physiol. Gastrointest. Liver Physiol. . 307 . 1 . G58–65 . 2014 . 24833709 . 4080163 . 10.1152/ajpgi.00373.2013 .

Notes and References

1. Web site: Entrez Gene: Sestrin 3. 2017-08-05.