SERPINI2 explained

Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Xiao G, Liu YE, Gentz R, Sang QA, Ni J, Goldberg ID, Shi YE . Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells . Proceedings of the National Academy of Sciences of the United States of America . 96 . 7 . 3700–5 . March 1999 . 10097100 . 22357 . 10.1073/pnas.96.7.3700 . 1999PNAS...96.3700X . free .
• Chang WS, Chang NT, Lin SC, Wu CW, Wu FY . Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26 . Genes, Chromosomes & Cancer . 29 . 3 . 240–55 . November 2000 . 10992299 . 10.1002/1098-2264(2000)9999:9999<::AID-GCC1029>3.0.CO;2-A . 23441111 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .

External links

• The MEROPS online database for peptidases and their inhibitors: I04.026

Notes and References

1. Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y . Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells . Genes, Chromosomes & Cancer . 22 . 3 . 179–85 . July 1998 . 9624529 . 10.1002/(SICI)1098-2264(199807)22:3<179::AID-GCC3>3.0.CO;2-T . 9525421 .
2. Web site: Entrez Gene: SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2.