SER-601 explained

SER-601 (COR-167) is a drug which acts as a potent and selective cannabinoid CB₂ receptor agonist, based on a quinolone-3-carboxylic acid core structure, with 190 times selectivity for CB₂ over the related CB₁ receptor. It has analgesic effects in animal studies, as well as neuroprotective effects,^[1] but without a "cannabis high" due to its low affinity for CB₁.^[2] A number of related compounds are known, almost all of which have high selectivity for CB₂.^[3]

See also

• A-836,339
• ADB-FUBHQUCA
• CBS-0550

Notes and References

1. Contartese A, Valoti M, Corelli F, Pasquini S, Mugnaini C, Pessina F, Aldinucci C, Sgaragli G, Frosini M . 6 . A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury . Pharmacological Research . 66 . 6 . 555–563 . December 2012 . 23036353 . 10.1016/j.phrs.2012.08.003 .
2. Pasquini S, Botta L, Semeraro T, Mugnaini C, Ligresti A, Palazzo E, Maione S, Di Marzo V, Corelli F . 6 . Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo . Journal of Medicinal Chemistry . 51 . 16 . 5075–5084 . August 2008 . 18680276 . 10.1021/jm800552f .
3. Pasquini S, Ligresti A, Mugnaini C, Semeraro T, Cicione L, De Rosa M, Guida F, Luongo L, De Chiaro M, Cascio MG, Bolognini D, Marini P, Pertwee R, Maione S, Di Marzo V, Corelli F . 6 . Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands . Journal of Medicinal Chemistry . 53 . 16 . 5915–5928 . August 2010 . 20718492 . 10.1021/jm100123x .