SEPX1 explained

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.^{[1] [2]}

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.^[2]

See also

• MSRA (gene)
• MSRB2
• Methionine oxidation

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Kryukov GV, Kryukov VM, Gladyshev VN . New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. . J. Biol. Chem. . 274 . 48 . 33888–97 . 1999 . 10567350 . 10.1074/jbc.274.48.33888 . free .
• Zhang QH, Ye M, Wu XY, etal . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 .
• Daniels RJ, Peden JF, Lloyd C, etal . Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. . Hum. Mol. Genet. . 10 . 4 . 339–52 . 2001 . 11157797 . 10.1093/hmg/10.4.339 . free .
• Moskovitz J, Singh VK, Requena J, etal . Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity. . Biochem. Biophys. Res. Commun. . 290 . 1 . 62–5 . 2002 . 11779133 . 10.1006/bbrc.2001.6171 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Kim HY, Gladyshev VN . Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. . Mol. Biol. Cell . 15 . 3 . 1055–64 . 2004 . 14699060 . 10.1091/mbc.E03-08-0629 . 363075 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Lescure A, Gautheret D, Carbon P, Krol A . Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif . J Biol Chem . 274 . 53 . 38147–54 . Feb 2000 . 10608886 . 10.1074/jbc.274.53.38147 . free .
2. Web site: Entrez Gene: SEPX1 selenoprotein X, 1.