SEPT8 explained

Septin-8 is a protein that in humans is encoded by the SEPT8 gene.^{[1] [2] [3]}

Function

SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking.

Interactions

SEPT8 has been shown to interact with PFTK1^[4] and SEPT5.^{[5] [6]}

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Wenderfer SE, Slack JP, McCluskey TS, Monaco JJ . Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11 . Genomics . 63 . 3 . 354–73 . February 2000 . 10704283 . 10.1006/geno.1999.6100 .
• Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B . Human septin-septin interaction: CDCrel-1 partners with KIAA0202 . FEBS Letters . 519 . 1–3 . 169–72 . May 2002 . 12023038 . 10.1016/S0014-5793(02)02749-7 . 30822245 . 2002FEBSL.519..169B .
• Yang T, Gao YK, Chen JY . KIAA0202, a human septin family member, interacting with hPFTAIRE1 . Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica . 34 . 4 . 520–5 . July 2002 . 12098780 .
• Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, Petty EM, Peifer M, Pringle JR, Robinson PJ, Roth D, Russell SE, Stuhlmann H, Tanaka M, Tanaka T, Trimble WS, Ware J, Zeleznik-Le NJ, Zieger B. Mary B. Kennedy . Mammalian septins nomenclature . Molecular Biology of the Cell . 13 . 12 . 4111–3 . December 2002 . 12475938 . 138619 . 10.1091/mbc.E02-07-0438 .
• Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B . Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202) . Gene . 312 . 313–20 . July 2003 . 12909369 . 10.1016/S0378-1119(03)00635-8 .
• Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B . The novel human platelet septin SEPT8 is an interaction partner of SEPT4 . Thrombosis and Haemostasis . 91 . 5 . 959–66 . May 2004 . 15116257 . 10.1160/TH03-09-0578 . 22853459 .
• Martínez C, Sanjuan MA, Dent JA, Karlsson L, Ware J . Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol . The Biochemical Journal . 382 . Pt 3 . 783–91 . September 2004 . 15214843 . 1133953 . 10.1042/BJ20040372 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Bläser S, Röseler S, Rempp H, Bartsch I, Bauer H, Lieber M, Lessmann E, Weingarten L, Busse A, Huber M, Zieger B . Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5 . The Journal of Pathology . 210 . 1 . 103–10 . September 2006 . 16767699 . 10.1002/path.2013 . 45797279 .
• Xin X, Pache M, Zieger B, Bartsch I, Prünte C, Flammer J, Meyer P . Septin expression in proliferative retinal membranes . The Journal of Histochemistry and Cytochemistry . 55 . 11 . 1089–94 . November 2007 . 17625225 . 10.1369/jhc.7A7188.2007 . 3957527 .

Notes and References

1. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain . DNA Research . 3 . 5 . 321–9, 341-54 . October 1996 . 9039502 . 10.1093/dnares/3.5.321 . free .
2. Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM . Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region . Genome Research . 7 . 5 . 495–512 . May 1997 . 9149945 . 10.1101/gr.7.5.495 . free .
3. Web site: Entrez Gene: SEPT8 septin 8.
4. Yang T, Gao YK, Chen JY . KIAA0202, a human septin family member, interacting with hPFTAIRE1 . Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica . 34 . 4 . 520–5 . July 2002 . 12098780 .
5. Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B . Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202) . Gene . 312 . 313–20 . July 2003 . 12909369 . 10.1016/S0378-1119(03)00635-8 .
6. Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B . Human septin-septin interaction: CDCrel-1 partners with KIAA0202 . FEBS Letters . 519 . 1–3 . 169–72 . May 2002 . 12023038 . 10.1016/S0014-5793(02)02749-7 . 30822245 . 2002FEBSL.519..169B .