SEPT7 explained

Septin-7 is a protein that in humans is encoded by the SEPT7 gene.^{[1] [2]}

Function

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. Although the exact function of this gene has not yet been determined, its high similarity to yeast CDC10 and the high conservative nature of eukaryotic cell cycle machinery suggest a similar role to that of its yeast counterpart. Alternative splicing results in two transcript variants encoding different isoforms.

Interactions

SEPT7 has been shown to interact with SEPT2^{[3] [4]} and SEPT9.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH . Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments . Neuron . 20 . 6 . 1111–22 . June 1998 . 9655500 . 10.1016/S0896-6273(00)80493-6 . 10915358 . free .
• Oegema K, Savoian MS, Mitchison TJ, Field CM . Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis . The Journal of Cell Biology . 150 . 3 . 539–52 . August 2000 . 10931866 . 2175195 . 10.1083/jcb.150.3.539 .
• Joberty G, Perlungher RR, Sheffield PJ, Kinoshita M, Noda M, Haystead T, Macara IG . Borg proteins control septin organization and are negatively regulated by Cdc42 . Nature Cell Biology . 3 . 10 . 861–6 . October 2001 . 11584266 . 10.1038/ncb1001-861 . 58805 .
• Surka MC, Tsang CW, Trimble WS . The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis . Molecular Biology of the Cell . 13 . 10 . 3532–45 . October 2002 . 12388755 . 129964 . 10.1091/mbc.E02-01-0042 .
• Koshelev YA, Kiselev SL, Georgiev GP . Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro . Doklady Biochemistry and Biophysics . 391 . 195–7 . 2004 . 14531065 . 10.1023/A:1025149005902 . 26291196 .
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions . Genome Research . 14 . 9 . 1711–8 . September 2004 . 15342556 . 515316 . 10.1101/gr.2435604 .
• Nagata K, Asano T, Nozawa Y, Inagaki M . Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11 . The Journal of Biological Chemistry . 279 . 53 . 55895–904 . December 2004 . 15485874 . 10.1074/jbc.M406153200 . free .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nature Biotechnology . 23 . 1 . 94–101 . January 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . January 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Low C, Macara IG . Structural analysis of septin 2, 6, and 7 complexes . The Journal of Biological Chemistry . 281 . 41 . 30697–706 . October 2006 . 16914550 . 10.1074/jbc.M605179200 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Sirajuddin M, Farkasovsky M, Hauer F, Kühlmann D, Macara IG, Weyand M, Stark H, Wittinghofer A . Structural insight into filament formation by mammalian septins . Nature . 449 . 7160 . 311–5 . September 2007 . 17637674 . 10.1038/nature06052 . 2007Natur.449..311S .
• Kremer BE, Adang LA, Macara IG . Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7 . Cell . 130 . 5 . 837–50 . September 2007 . 17803907 . 2085444 . 10.1016/j.cell.2007.06.053 .

Notes and References

1. Nakatsuru S, Sudo K, Nakamura Y . Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae . Biochemical and Biophysical Research Communications . 202 . 1 . 82–7 . July 1994 . 8037772 . 10.1006/bbrc.1994.1896 .
2. Web site: Entrez Gene: SEPT7 septin 7.
3. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 89 . 17353931 . 1847948 . 10.1038/msb4100134 . 2007 .
4. Surka MC, Tsang CW, Trimble WS . The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis . Molecular Biology of the Cell . 13 . 10 . 3532–45 . October 2002 . 12388755 . 129964 . 10.1091/mbc.E02-01-0042 .