SEPT4 explained

Septin-4 is a protein that in humans is encoded by the SEPT4 gene.^{[1] [2]}

Function

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. The protein encoded by this gene is thought to be part of a complex involved in cytokinesis. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[2]

Further reading

• Xie H, Surka M, Howard J, Trimble WS . Characterization of the mammalian septin H5: distinct patterns of cytoskeletal and membrane association from other septin proteins . Cell Motility and the Cytoskeleton . 43 . 1 . 52–62 . 1999 . 10340703 . 10.1002/(SICI)1097-0169(1999)43:1<52::AID-CM6>3.0.CO;2-5 .
• Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, Gottfried Y, Birkey Reffey S, de Caestecker MP, Danielpour D, Book-Melamed N, Timberg R, Duckett CS, Lechleider RJ, Steller H, Orly J, Kim SJ, Roberts AB . A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif . Nature Cell Biology . 2 . 12 . 915–21 . December 2000 . 11146656 . 10.1038/35046566 . 12321788 .
• Zieger B, Tran H, Hainmann I, Wunderle D, Zgaga-Griesz A, Blaser S, Ware J . Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2 . Gene . 261 . 2 . 197–203 . December 2000 . 11167005 . 10.1016/S0378-1119(00)00527-8 .
• Tanaka M, Tanaka T, Kijima H, Itoh J, Matsuda T, Hori S, Yamamoto M . Characterization of tissue- and cell-type-specific expression of a novel human septin family gene, Bradeion . Biochemical and Biophysical Research Communications . 286 . 3 . 547–53 . August 2001 . 11511094 . 10.1006/bbrc.2001.5413 .
• Tanaka M, Kijima H, Itoh J, Matsuda T, Tanaka T . Impaired expression of a human septin family gene Bradeion inhibits the growth and tumorigenesis of colorectal cancer in vitro and in vivo . Cancer Gene Therapy . 9 . 6 . 483–8 . June 2002 . 12032658 . 10.1038/sj.cgt.7700460 . free .
• Vega IE, Hsu SC . The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells . NeuroReport . 14 . 1 . 31–7 . January 2003 . 12544826 . 10.1097/00001756-200301200-00006 . 22757290 .
• Ihara M, Tomimoto H, Kitayama H, Morioka Y, Akiguchi I, Shibasaki H, Noda M, Kinoshita M . Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies . The Journal of Biological Chemistry . 278 . 26 . 24095–102 . June 2003 . 12695511 . 10.1074/jbc.M301352200 . free .
• Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B . Ted M. Dawson . Benjamin Wolozin . SEPT5_v2 is a parkin-binding protein . Brain Research. Molecular Brain Research . 117 . 2 . 179–89 . October 2003 . 14559152 . 10.1016/S0169-328X(03)00318-8 .
• Gottfried Y, Rotem A, Lotan R, Steller H, Larisch S . The mitochondrial ARTS protein promotes apoptosis through targeting XIAP . The EMBO Journal . 23 . 7 . 1627–35 . April 2004 . 15029247 . 391065 . 10.1038/sj.emboj.7600155 .
• Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B . The novel human platelet septin SEPT8 is an interaction partner of SEPT4 . Thrombosis and Haemostasis . 91 . 5 . 959–66 . May 2004 . 15116257 . 10.1160/TH03-09-0578 . 22853459 .
• Elhasid R, Sahar D, Merling A, Zivony Y, Rotem A, Ben-Arush M, Izraeli S, Bercovich D, Larisch S . Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients . Oncogene . 23 . 32 . 5468–75 . July 2004 . 15122323 . 10.1038/sj.onc.1207725 . free .
• Martínez C, Sanjuan MA, Dent JA, Karlsson L, Ware J . Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol . The Biochemical Journal . 382 . Pt 3 . 783–91 . September 2004 . 15214843 . 1133953 . 10.1042/BJ20040372 .
• Lotan R, Rotem A, Gonen H, Finberg JP, Kemeny S, Steller H, Ciechanover A, Larisch S . Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation . The Journal of Biological Chemistry . 280 . 27 . 25802–10 . July 2005 . 15837787 . 10.1074/jbc.M501955200 . free .
• Lee JW, Soung YH, Young Kim S, Woo Nam S, Sang Park W, Young Lee J, Jin Yoo N, Lee SH . Mutational analysis of proapoptotic ARTS P-loop domain in common human cancers . Pathology, Research and Practice . 202 . 2 . 67–70 . 2006 . 16376484 . 10.1016/j.prp.2005.11.001 .
• Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH . Mutational analysis of P-loop domains of proapoptotic Nod1 and ARTS genes in colon carcinomas . Acta Oncologica . 45 . 1 . 101–2 . 2006 . 16464805 . 10.1080/02841860500374497 . 218896700 .
• Garcia W, de Araújo AP, Neto Mde O, Ballestero MR, Polikarpov I, Tanaka M, Tanaka T, Garratt RC . Dissection of a human septin: definition and characterization of distinct domains within human SEPT4 . Biochemistry . 45 . 46 . 13918–31 . November 2006 . 17105210 . 10.1021/bi061549z .

Notes and References

1. Paavola P, Horelli-Kuitunen N, Palotie A, Peltonen L . Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene . Genomics . 55 . 1 . 122–5 . January 1999 . 9889007 . 10.1006/geno.1998.5612 .
2. Web site: Entrez Gene: SEPT4 septin 4.