SEPT12 explained

Septin 12 is a protein that in humans is encoded by the SEPT12 gene.^[1]

Function

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

Further reading

• Kuo PL, Chiang HS, Wang YY, Kuo YC, Chen MF, Yu IS, Teng YN, Lin SW, Lin YH . SEPT12-microtubule complexes are required for sperm head and tail formation . International Journal of Molecular Sciences . 14 . 11 . 22102–16 . 2013 . 24213608 . 3856054 . 10.3390/ijms141122102 . free .
• Hall PA, Jung K, Hillan KJ, Russell SE . Expression profiling the human septin gene family . The Journal of Pathology . 206 . 3 . 269–78 . July 2005 . 15915442 . 10.1002/path.1789 . 42206750 .
• Kinoshita M . The septins . Genome Biology . 4 . 11 . 236 . 2003 . 14611653 . 329110 . 10.1186/gb-2003-4-11-236 . free .
• Ding X, Yu W, Liu M, Shen S, Chen F, Wan B, Yu L . SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells . Journal of Biochemistry and Molecular Biology . 40 . 6 . 973–8 . November 2007 . 18047794 . 10.5483/bmbrep.2007.40.6.973 . free .
• Kuo YC, Lin YH, Chen HI, Wang YY, Chiou YW, Lin HH, Pan HA, Wu CM, Su SM, Hsu CC, Kuo PL . SEPT12 mutations cause male infertility with defective sperm annulus . Human Mutation . 33 . 4 . 710–9 . April 2012 . 22275165 . 10.1002/humu.22028 . 7923473 . free .
• Miyakawa H, Miyamoto T, Koh E, Tsujimura A, Miyagawa Y, Saijo Y, Namiki M, Sengoku K . Single-nucleotide polymorphisms in the SEPTIN12 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome . Journal of Andrology . 33 . 3 . 483–7 . 2012 . 21636737 . 10.2164/jandrol.110.012146 . free .
• Lin YH, Wang YY, Chen HI, Kuo YC, Chiou YW, Lin HH, Wu CM, Hsu CC, Chiang HS, Kuo PL . SEPTIN12 genetic variants confer susceptibility to teratozoospermia . PLOS ONE . 7 . 3 . e34011 . 2012 . 22479503 . 3316533 . 10.1371/journal.pone.0034011 . 2012PLoSO...734011L . free .
• Lin YH, Lin YM, Wang YY, Yu IS, Lin YW, Wang YH, Wu CM, Pan HA, Chao SC, Yen PH, Lin SW, Kuo PL . The expression level of septin12 is critical for spermiogenesis . The American Journal of Pathology . 174 . 5 . 1857–68 . May 2009 . 19359518 . 2671274 . 10.2353/ajpath.2009.080955 .
• Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Namiki M, Horikawa M, Saijo Y, Sengoku K . Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men . Journal of Assisted Reproduction and Genetics . 29 . 1 . 47–51 . January 2012 . 22116646 . 3252415 . 10.1007/s10815-011-9679-5 .

Notes and References

1. Web site: Entrez Gene: Septin 12 .