SEPT10 explained

Septin 10 is a protein that in humans is encoded by the SEPT10 gene.^[1]

Function

This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternative splicing results in multiple transcript variants.^[1]

Further reading

• Sui L, Zhang W, Liu Q, Chen T, Li N, Wan T, Yu M, Cao X . Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells . Biochemical and Biophysical Research Communications . 304 . 2 . 393–8 . May 2003 . 12711328 . 10.1016/s0006-291x(03)00601-6 .
• Benedetti D, Bomben R, Dal-Bo M, Marconi D, Zucchetto A, Degan M, Forconi F, Del-Poeta G, Gaidano G, Gattei V . Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10 . Leukemia . 22 . 1 . 224–6 . January 2008 . 17657217 . 10.1038/sj.leu.2404867 .
• Xu M, Takanashi M, Oikawa K, Nishi H, Isaka K, Yoshimoto T, Ohyashiki J, Kuroda M . Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen . Cancer Science . 103 . 4 . 821–7 . April 2012 . 22320903 . 10.1111/j.1349-7006.2012.02221.x . 7659246 . 3456503 . free .

Notes and References

1. Web site: Entrez Gene: Septin 10 .