SEPTIN1 explained

Septin-1 is a protein that in humans is encoded by the SEPTIN1 gene.^{[1] [2]} It was renamed from SEPT1 to avoid problems where Microsoft Excel would auto-correct the gene name to the date September 1.^[3]

Function

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.^[2]

Further reading

• Nottenburg C, Gallatin WM, St John T . Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences . Gene . 95 . 2 . 279–84 . November 1990 . 2174398 . 10.1016/0378-1119(90)90372-X .
• Kinoshita A, Kinoshita M, Akiyama H, Tomimoto H, Akiguchi I, Kumar S, Noda M, Kimura J . Identification of septins in neurofibrillary tangles in Alzheimer's disease . The American Journal of Pathology . 153 . 5 . 1551–60 . November 1998 . 9811347 . 1853406 . 10.1016/S0002-9440(10)65743-4 .
• Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ . Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression . Cancer Immunity . 1 . 4 . March 2001 . 12747765 .
• Qi M, Yu W, Liu S, Jia H, Tang L, Shen M, Yan X, Saiyin H, Lang Q, Wan B, Zhao S, Yu L . Septin1, a new interaction partner for human serine/threonine kinase aurora-B . Biochemical and Biophysical Research Communications . 336 . 3 . 994–1000 . October 2005 . 16179162 . 10.1016/j.bbrc.2005.06.212 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kato Y, Uzawa K, Yamamoto N, Kouzu Y, Koike H, Shiiba M, Bukawa H, Yokoe H, Shibahara T, Tanzawa H . Overexpression of Septin1: possible contribution to the development of oral cancer . International Journal of Oncology . 31 . 5 . 1021–8 . November 2007 . 17912427 . 10.3892/ijo.31.5.1021 . free .

Notes and References

1. Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y . Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6 . Cytogenetics and Cell Genetics . 73 . 3 . 224–7 . Sep 1996 . 8697812 . 10.1159/000134343 .
2. Web site: Entrez Gene: SEPT1 septin 1.
3. Web site: Scientists rename human genes to stop Microsoft Excel from misreading them as dates . 2022-10-24 . the Verge . en-US. James. Vincent. 6 August 2020 .