SENP6 explained

Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene.^[1]

Function

Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins

See also

• small ubiquitin-related modifier 1

Further reading

• Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS . Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs . The Journal of Biological Chemistry . 282 . 36 . 26217–24 . September 2007 . 17591783 . 10.1074/jbc.M702444200 . free .
• Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS . Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family . The Biochemical Journal . 409 . 2 . 461–9 . January 2008 . 17916063 . 10.1042/BJ20070940 . 12234952 .
• Yeh ET, Gong L, Kamitani T . Ubiquitin-like proteins: new wines in new bottles . Gene . 248 . 1–2 . 1–14 . May 2000 . 10806345 . 10.1016/S0378-1119(00)00139-6 .
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 5 . 5 . 277–86 . October 1998 . 9872452 . 10.1093/dnares/5.5.277 . free .
• Kim KI, Baek SH, Jeon YJ, Nishimori S, Suzuki T, Uchida S, Shimbara N, Saitoh H, Tanaka K, Chung CH . A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs . The Journal of Biological Chemistry . 275 . 19 . 14102–6 . May 2000 . 10799485 . 10.1074/jbc.275.19.14102 . free .
• Goodson ML, Hong Y, Rogers R, Matunis MJ, Park-Sarge OK, Sarge KD . Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor . The Journal of Biological Chemistry . 276 . 21 . 18513–8 . May 2001 . 11278381 . 10.1074/jbc.M008066200 . free .
• Tojo M, Matsuzaki K, Minami T, Honda Y, Yasuda H, Chiba T, Saya H, Fujii-Kuriyama Y, Nakao M . The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system . The Journal of Biological Chemistry . 277 . 48 . 46576–85 . November 2002 . 12354770 . 10.1074/jbc.M205987200 . free .
• Bailey D, O'Hare P . Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1 . The Journal of Biological Chemistry . 279 . 1 . 692–703 . January 2004 . 14563852 . 10.1074/jbc.M306195200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Choi SJ, Chung SS, Rho EJ, Lee HW, Lee MH, Choi HS, Seol JH, Baek SH, Bang OS, Chung CH . Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1 . The Journal of Biological Chemistry . 281 . 41 . 30669–77 . October 2006 . 16912044 . 10.1074/jbc.M604033200 . free .
• Mukhopadhyay D, Ayaydin F, Kolli N, Tan SH, Anan T, Kametaka A, Azuma Y, Wilkinson KD, Dasso M . SUSP1 antagonizes formation of highly SUMO2/3-conjugated species . The Journal of Cell Biology . 174 . 7 . 939–49 . September 2006 . 17000875 . 2064386 . 10.1083/jcb.200510103 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Web site: Entrez Gene: SENP6 SUMO1/sentrin specific peptidase 6.