SENP3 explained

SUMO1/sentrin/SMT3 specific peptidase 3, also known as SENP3, is a protein which in humans is encoded by the SENP3 gene.^{[1] [2]}

SENP3 together with SENP5, belongs to the Ulp1 branch in yeast and localize to nucleolus through B23/NPM1. SENP3 is associated and regulated by B23/nucleophosmin/NPM1 and involved in the regulation of ribosome biogenesis. SENP3 may be regulated by Arf-Mdm2-p53 pathway.^[3]

Further reading

• Yeh ET, Gong L, Kamitani T . Ubiquitin-like proteins: new wines in new bottles . Gene . 248 . 1–2 . 1–14 . 2000 . 10806345 . 10.1016/S0378-1119(00)00139-6 .
• Nishida T, Tanaka H, Yasuda H . A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase . Eur. J. Biochem. . 267 . 21 . 6423–7 . 2000 . 11029585 . 10.1046/j.1432-1327.2000.01729.x . free .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Simpson JC, Wellenreuther R, Poustka A, etal . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Bouras T, Fu M, Sauve AA, etal . SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1 . J. Biol. Chem. . 280 . 11 . 10264–76 . 2005 . 15632193 . 10.1074/jbc.M408748200 . free .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Grégoire S, Yang XJ . Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors . Mol. Cell. Biol. . 25 . 6 . 2273–87 . 2005 . 15743823 . 10.1128/MCB.25.6.2273-2287.2005 . 1061617 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Nousiainen M, Silljé HH, Sauer G, etal . Phosphoproteome analysis of the human mitotic spindle . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . 2006PNAS..103.5391N . free .
• Gong L, Yeh ET . Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3 . J. Biol. Chem. . 281 . 23 . 15869–77 . 2006 . 16608850 . 10.1074/jbc.M511658200 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Yun C, Wang Y, Mukhopadhyay D, etal . Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases . J. Cell Biol. . 183 . 4 . 589–95 . 2008 . 19015314 . 10.1083/jcb.200807185 . 2582899 .
• Haindl M, Harasim T, Eick D, Muller S . The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing . EMBO Rep. . 9 . 3 . 273–9 . March 2008 . 18259216 . 10.1038/embor.2008.3 . 2267381 .
• Kuo ML, den Besten W, Thomas MC, etal . Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3 . Cell Cycle . 7 . 21 . 3378–87 . 2008 . 18948745 . 10.4161/cc.7.21.6930. free .

Notes and References

1. Yeh ET, Gong L, Kamitani T . Ubiquitin-like proteins: new wines in new bottles . Gene . 248 . 1–2 . 1–14 . May 2000 . 10806345 . 10.1016/S0378-1119(00)00139-6.
2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . March 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
3. Web site: Entrez Gene: SENP3 SUMO1/sentrin/SMT3 specific peptidase 3.