SENP2 explained

Sentrin-specific protease 2 is an enzyme that in humans is encoded by the SENP2 gene.^{[1] [2] [3]}

Function

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of protease enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM]^[3]

Interactions

SENP2 has been shown to interact with NUP153.^[4]

Further reading

• Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS . Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs . J. Biol. Chem. . 282 . 36 . 26217–24 . 2007 . 17591783 . 10.1074/jbc.M702444200 . free .
• Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS . Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family . Biochem. J. . 409 . 2 . 461–9 . 2008 . 17916063 . 10.1042/BJ20070940 . 12234952 .
• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2002 . 12168954 . 10.1093/dnares/9.3.99 . 10.1.1.500.923 .
• Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 1 . 65–73 . 2000 . 10718198 . 10.1093/dnares/7.1.65 . free .
• Kadoya T, Yamamoto H, Suzuki T, Yukita A, Fukui A, Michiue T, Asahara T, Tanaka K, Asashima M, Kikuchi A . Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin . Mol. Cell. Biol. . 22 . 11 . 3803–19 . 2002 . 11997515 . 133821 . 10.1128/MCB.22.11.3803-3819.2002 .
• Zhang H, Saitoh H, Matunis MJ . Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex . Mol. Cell. Biol. . 22 . 18 . 6498–508 . 2002 . 12192048 . 135644 . 10.1128/MCB.22.18.6498-6508.2002 .
• Best JL, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, Meluh PB, Pandolfi PP, Zon LI . SUMO-1 protease-1 regulates gene transcription through PML . Mol. Cell . 10 . 4 . 843–55 . 2002 . 12419228 . 10.1016/S1097-2765(02)00699-8 . free .
• Reverter D, Lima CD . A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex . Structure . 12 . 8 . 1519–31 . 2004 . 15296745 . 10.1016/j.str.2004.05.023 . free .
• Itahana Y, Yeh ET, Zhang Y . Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2 . Mol. Cell. Biol. . 26 . 12 . 4675–89 . 2006 . 16738331 . 1489137 . 10.1128/MCB.01830-05 .
• Reverter D, Lima CD . Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates . Nat. Struct. Mol. Biol. . 13 . 12 . 1060–8 . 2006 . 17099700 . 10.1038/nsmb1168 . 25139166 .

Notes and References

1. Hang J, Dasso M . Association of the human SUMO-1 protease SENP2 with the nuclear pore . J. Biol. Chem. . 277 . 22 . 19961–6 . May 2002 . 11896061 . 10.1074/jbc.M201799200 . free .
2. Nishida T, Kaneko F, Kitagawa M, Yasuda H . Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation . J. Biol. Chem. . 276 . 42 . 39060–6 . October 2001 . 11489887 . 10.1074/jbc.M103955200 . free.
3. Web site: Entrez Gene: SENP2 SUMO1/sentrin/SMT3 specific peptidase 2.
4. Zhang H, Saitoh H, Matunis MJ . Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex . Mol. Cell. Biol. . 22 . 18 . 6498–508 . September 2002 . 12192048 . 135644 . 10.1128/MCB.22.18.6498-6508.2002 .