SEMG2 explained

Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene.^{[1] [2]}

The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.^[3]

See also

• Semenogelin

Further reading

• Lilja H, Lundwall A . Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein . Proc. Natl. Acad. Sci. U.S.A. . 89 . 10 . 4559–63 . 1992 . 1584792 . 10.1073/pnas.89.10.4559 . 49122 . 1992PNAS...89.4559L . free .
• Schneider K, Kausler W, Tripier D, etal . [Isolation and structure determination of two peptides occurring in human seminal plasma] . Biol. Chem. Hoppe-Seyler . 370 . 4 . 353–6 . 1989 . 2757795 . 10.1515/bchm3.1989.370.1.353.
• Lundwall A . The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA . Eur. J. Biochem. . 235 . 3 . 466–70 . 1996 . 8654389 . 10.1111/j.1432-1033.1996.00466.x . free .
• Malm J, Hellman J, Magnusson H, etal . Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II . Eur. J. Biochem. . 238 . 1 . 48–53 . 1996 . 8665951 . 10.1111/j.1432-1033.1996.0048q.x . free .
• Kise H, Nishioka J, Kawamura J, Suzuki K . Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor . Eur. J. Biochem. . 238 . 1 . 88–96 . 1996 . 8665956 . 10.1111/j.1432-1033.1996.0088q.x . free .
• Bjartell A, Malm J, Moller C, etal . Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry . J. Androl. . 17 . 1 . 17–26 . 1997 . 10.1002/j.1939-4640.1996.tb00582.x . 8833737 . 20337870 .
• Ulvsbäck M, Lundwall A . Cloning of the semenogelin II gene of the rhesus monkey. Duplications of 360 bp extend the coding region in man, rhesus monkey and baboon . Eur. J. Biochem. . 245 . 1 . 25–31 . 1997 . 9128720 . 10.1111/j.1432-1033.1997.00025.x .
• Lövgren J, Airas K, Lilja H . Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors . Eur. J. Biochem. . 262 . 3 . 781–9 . 1999 . 10411640 . 10.1046/j.1432-1327.1999.00433.x . free .
• Malm J, Hellman J, Hogg P, Lilja H . Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor . Prostate . 45 . 2 . 132–9 . 2000 . 11027412 . 10.1002/1097-0045(20001001)45:2<132::AID-PROS7>3.0.CO;2-3 . 35309283 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Brillard-Bourdet M, Réhault S, Juliano L, etal . Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates . Eur. J. Biochem. . 269 . 1 . 390–5 . 2002 . 11784334 . 10.1046/j.0014-2956.2001.02667.x . free .
• Lundwall A, Bjartell A, Olsson AY, Malm J . Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues . Mol. Hum. Reprod. . 8 . 9 . 805–10 . 2003 . 12200457 . 10.1093/molehr/8.9.805 .
• Ek P, Malm J, Lilja H, etal . Exogenous protein kinases A and C, but not endogenous prostasome-associated protein kinase, phosphorylate semenogelins I and II from human semen . J. Androl. . 23 . 6 . 806–14 . 2003 . 10.1002/j.1939-4640.2002.tb02337.x . 12399526 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yoshida K, Yamasaki T, Yoshiike M, etal . Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma . J. Androl. . 24 . 6 . 878–84 . 2004 . 14581514 . 10.1002/j.1939-4640.2003.tb03139.x. free .
• Jensen-Seaman MI, Li WH . Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen . J. Mol. Evol. . 57 . 3 . 261–70 . 2004 . 14629036 . 10.1007/s00239-003-2474-x . 10.1.1.328.9582 . 9728983 .
• Dorus S, Evans PD, Wyckoff GJ, etal . Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity . Nat. Genet. . 36 . 12 . 1326–9 . 2005 . 15531881 . 10.1038/ng1471 . 9122060 .
• Jonsson M, Linse S, Frohm B, etal . Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen . Biochem. J. . 387 . Pt 2 . 447–53 . 2005 . 15563730 . 10.1042/BJ20041424 . 1134973 .

Notes and References

1. Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A . Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20 . J Biol Chem . 267 . 25 . 18080–4 . Oct 1992 . 10.1016/S0021-9258(19)37155-8 . 1517240 . free .
2. Peter A, Lilja H, Lundwall A, Malm J . Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase . Eur J Biochem . 252 . 2 . 216–21 . Apr 1998 . 9523691 . 10.1046/j.1432-1327.1998.2520216.x . free .
3. Web site: Entrez Gene: SEMG2 semenogelin II.