SEMA6A explained

Semaphorin-6A is a protein that in humans is encoded by the SEMA6A gene.^{[1] [2] [3]}

In melanocytic cells SEMA6A gene expression may be regulated by MITF.^[4]

Further reading

• Prislei S, Mozzetti S, Filippetti F, etal . From plasma membrane to cytoskeleton: a novel function for semaphorin 6A. . Mol. Cancer Ther. . 7 . 1 . 233–41 . 2008 . 18187809 . 10.1158/1535-7163.MCT-07-0390 . free .
• Katoh M, Katoh M . Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. . Int. J. Mol. Med. . 20 . 3 . 405–9 . 2007 . 17671748 . 10.3892/ijmm.20.3.405. free .
• Gautier G, de Saint-Vis B, Sénéchal B, etal . The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations. . Am. J. Pathol. . 168 . 2 . 453–65 . 2006 . 16436660 . 10.2353/ajpath.2006.050288 . 1606484 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. . Genome Res. . 12 . 11 . 1773–84 . 2003 . 12421765 . 10.1101/gr.406902 . 187542 .
• Nagase T, Kikuno R, Ishikawa KI, etal . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 7 . 1 . 65–73 . 2000 . 10718198 . 10.1093/dnares/7.1.65 . free .

Notes and References

1. Zhou L, White FA, Lentz SI, Wright DE, Fisher DA, Snider WD . Cloning and expression of a novel murine semaphorin with structural similarity to insect semaphorin I . Mol Cell Neurosci . 9 . 1 . 26–41 . Sep 1997 . 9204478 . 10.1006/mcne.1997.0607 . 38730386 .
2. Klostermann A, Lutz B, Gertler F, Behl C . The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain . J Biol Chem . 275 . 50 . 39647–53 . Jan 2001 . 10993894 . 10.1074/jbc.M006316200 . free .
3. Web site: Entrez Gene: SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A.
4. Hoek KS, Schlegel NC, Eichhoff OM, etal . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell Melanoma Res. . 21 . 6 . 665–76 . 2008 . 19067971 . 10.1111/j.1755-148X.2008.00505.x . 24698373 . free .