SEMA5A explained

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.^{[1] [2] [3]}

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development.^[4]

Semaphorin 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions.^{[5] [6]}

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Simmons AD, Overhauser J, Lovett M . Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library . Genome Research . 7 . 2 . 118–127 . February 1997 . 9049630 . 10.1101/gr.7.2.118 . free .
• Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, Comoglio PM, Tamagnone L . 6 . Plexin-B3 is a functional receptor for semaphorin 5A . EMBO Reports . 5 . 7 . 710–714 . July 2004 . 15218527 . 1299100 . 10.1038/sj.embor.7400189 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . 6 . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–12135 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . free . 2004PNAS..10112130B .
• Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM . 6 . The DNA sequence and comparative analysis of human chromosome 5 . Nature . 431 . 7006 . 268–274 . September 2004 . 15372022 . 10.1038/nature02919 . free . 2004Natur.431..268S .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . 6 . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Melin M, Carlsson B, Anckarsater H, Rastam M, Betancur C, Isaksson A, Gillberg C, Dahl N . 6 . Constitutional downregulation of SEMA5A expression in autism . Neuropsychobiology . 54 . 1 . 64–69 . 2007 . 17028446 . 2553518 . 10.1159/000096040 .

Notes and References

1. Adams RH, Betz H, Püschel AW . A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis . Mechanisms of Development . 57 . 1 . 33–45 . June 1996 . 8817451 . 10.1016/0925-4773(96)00525-4 . 17827262 . free .
2. Simmons AD, Püschel AW, McPherson JD, Overhauser J, Lovett M . Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval . Biochemical and Biophysical Research Communications . 242 . 3 . 685–691 . January 1998 . 9464278 . 10.1006/bbrc.1997.8027 .
3. Web site: Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A.
4. Web site: Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A.
5. Mosca-Boidron AL, Gueneau L, Huguet G, Goldenberg A, Henry C, Gigot N, Pallesi-Pocachard E, Falace A, Duplomb L, Thevenon J, Duffourd Y, St-Onge J, Chambon P, Rivière JB, Thauvin-Robinet C, Callier P, Marle N, Payet M, Ragon C, Goubran Botros H, Buratti J, Calderari S, Dumas G, Delorme R, Lagarde N, Pinoit JM, Rosier A, Masurel-Paulet A, Cardoso C, Mugneret F, Saugier-Veber P, Campion D, Faivre L, Bourgeron T . 6 . A de novo microdeletion of SEMA5A in a boy with autism spectrum disorder and intellectual disability . European Journal of Human Genetics . 24 . 6 . 838–843 . June 2016 . 26395558 . 4867450 . 10.1038/ejhg.2015.211 .
6. Carulli D, de Winter F, Verhaagen J . Semaphorins in Adult Nervous System Plasticity and Disease . Frontiers in Synaptic Neuroscience . 13 . 672891 . 2021 . 34045951 . 8148045 . 10.3389/fnsyn.2021.672891 . free .