SEMA3F explained

Semaphorin-3F is a protein that in humans is encoded by the SEMA3F gene.^{[1] [2] [3]}

The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993). Sequence comparisons have grouped the secreted semaphorins into 3 general classes (classes 2, 3 and V), all of which also have an immunoglobulin domain. The semaphorin 3 family, consisting of human semaphorins 3A-G (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins 3A-G, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM]

Further reading

• Goshima Y, Nakamura F, Strittmatter P, Strittmatter SM . Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. . Nature . 376 . 6540 . 509–14 . 1995 . 7637782 . 10.1038/376509a0 . 1995Natur.376..509G . 4309140 .
• Kolodkin AL, Matthes DJ, Goodman CS . The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. . Cell . 75 . 7 . 1389–99 . 1994 . 8269517 . 10.1016/0092-8674(93)90625-Z . 21047504 .
• Luo Y, Raible D, Raper JA . Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. . Cell . 75 . 2 . 217–27 . 1993 . 8402908 . 10.1016/0092-8674(93)80064-L . 46120825 . free .
• Sekido Y, Bader S, Latif F, etal . Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. . Proc. Natl. Acad. Sci. U.S.A. . 93 . 9 . 4120–5 . 1996 . 8633026 . 10.1073/pnas.93.9.4120 . 39497 . 1996PNAS...93.4120S . free .
• Chen H, He Z, Bagri A, Tessier-Lavigne M . Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. . Neuron . 21 . 6 . 1283–90 . 1999 . 9883722 . 10.1016/S0896-6273(00)80648-0 . free .
• Hirsch E, Hu LJ, Prigent A, etal . Distribution of semaphorin IV in adult human brain. . Brain Res. . 823 . 1–2 . 67–79 . 1999 . 10095013 . 10.1016/S0006-8993(99)01103-8 . 46511802 .
• Brambilla E, Constantin B, Drabkin H, Roche J . Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration. . Am. J. Pathol. . 156 . 3 . 939–50 . 2000 . 10702410 . 10.1016/S0002-9440(10)64962-0. 1876858 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nasarre P, Constantin B, Rouhaud L, etal . Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading. . Neoplasia . 5 . 1 . 83–92 . 2003 . 12659673 . 10.1016/s1476-5586(03)80020-9. 1502125 .
• Lantuéjoul S, Constantin B, Drabkin H, etal . Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines. . J. Pathol. . 200 . 3 . 336–47 . 2003 . 12845630 . 10.1002/path.1367 . 1283756 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Bielenberg DR, Hida Y, Shimizu A, etal . Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. . J. Clin. Invest. . 114 . 9 . 1260–71 . 2004 . 15520858 . 10.1172/JCI21378 . 524226 .
• Gu C, Yoshida Y, Livet J, etal . Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. . Science . 307 . 5707 . 265–8 . 2005 . 15550623 . 10.1126/science.1105416 . 2005Sci...307..265G . 36470855 . free .
• Pope SN, Lee IR . Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. . J. Steroid Biochem. Mol. Biol. . 94 . 1–3 . 203–8 . 2005 . 15862967 . 10.1016/j.jsbmb.2005.01.007 . 9746088 .
• Kusy S, Nasarre P, Chan D, etal . Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells. . Neoplasia . 7 . 5 . 457–65 . 2005 . 15967098 . 10.1593/neo.04721 . 1501157 .
• Futamura M, Kamino H, Miyamoto Y, etal . Possible role of semaphorin 3F, a candidate tumor suppressor gene at 3p21.3, in p53-regulated tumor angiogenesis suppression. . Cancer Res. . 67 . 4 . 1451–60 . 2007 . 17308083 . 10.1158/0008-5472.CAN-06-2485 . free .
• Guttmann-Raviv N, Shraga-Heled N, Varshavsky A, etal . Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis. . J. Biol. Chem. . 282 . 36 . 26294–305 . 2007 . 17569671 . 10.1074/jbc.M609711200 . free .
• Menon L, Mihailescu MR . Interactions of the G quartet forming semaphorin 3F RNA with the RGG box domain of the fragile X protein family. . Nucleic Acids Res. . 35 . 16 . 5379–92 . 2007 . 17693432 . 10.1093/nar/gkm581 . 2018618 .

Notes and References

1. Xiang RH, Hensel CH, Garcia DK, Carlson HC, Kok K, Daly MC, Kerbacher K, van den Berg A, Veldhuis P, Buys CH, Naylor SL . Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer . Genomics . 32 . 1 . 39–48 . Sep 1996 . 8786119 . 10.1006/geno.1996.0074 .
2. Roche J, Boldog F, Robinson M, Robinson L, Varella-Garcia M, Swanton M, Waggoner B, Fishel R, Franklin W, Gemmill R, Drabkin H . Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin . Oncogene . 12 . 6 . 1289–97 . Jul 1996 . 8649831 .
3. Web site: Entrez Gene: SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F.