SEMA3B explained

Semaphorin-3B is a protein that in humans is encoded by the SEMA3B gene.^{[1] [2] [3]}

Function

The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.

Further reading

• Wei MH, Latif F, Bader S, Kashuba V, Chen JY, Duh FM, Sekido Y, Lee CC, Geil L, Kuzmin I, Zabarovsky E, Klein G, Zbar B, Minna JD, Lerman MI . Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG . Cancer Research . 56 . 7 . 1487–92 . April 1996 . 8603390 .
• Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM . Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors . Nature Neuroscience . 1 . 6 . 487–93 . October 1998 . 10196546 . 10.1038/2203 . 38320889 .
• Lerman MI, Minna JD . The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium . Cancer Research . 60 . 21 . 6116–33 . November 2000 . 11085536 .
• Tomizawa Y, Sekido Y, Kondo M, Gao B, Yokota J, Roche J, Drabkin H, Lerman MI, Gazdar AF, Minna JD . Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B . Proceedings of the National Academy of Sciences of the United States of America . 98 . 24 . 13954–9 . November 2001 . 11717452 . 61148 . 10.1073/pnas.231490898 . 2001PNAS...9813954T . free .
• Tse C, Xiang RH, Bracht T, Naylor SL . Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line . Cancer Research . 62 . 2 . 542–6 . January 2002 . 11809707 .
• Ochi K, Mori T, Toyama Y, Nakamura Y, Arakawa H . Identification of semaphorin3B as a direct target of p53 . Neoplasia . 4 . 1 . 82–7 . 2002 . 11922394 . 1503310 . 10.1038/sj.neo.7900211.
• Kuroki T, Trapasso F, Yendamuri S, Matsuyama A, Alder H, Williams NN, Kaiser LR, Croce CM . Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer . Cancer Research . 63 . 12 . 3352–5 . June 2003 . 12810670 .
• Castro-Rivera E, Ran S, Thorpe P, Minna JD . Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect . Proceedings of the National Academy of Sciences of the United States of America . 101 . 31 . 11432–7 . August 2004 . 15273288 . 509218 . 10.1073/pnas.0403969101 . 2004PNAS..10111432C . free .
• Marsit CJ, Wiencke JK, Liu M, Kelsey KT . The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans . Carcinogenesis . 26 . 8 . 1446–9 . August 2005 . 15831529 . 10.1093/carcin/bgi098 . free . 10.1.1.537.2049 .
• Nair PN, McArdle L, Cornell J, Cohn SL, Stallings RL . High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene . Cancer Genetics and Cytogenetics . 174 . 2 . 100–10 . April 2007 . 17452250 . 10.1016/j.cancergencyto.2006.11.017 .

Notes and References

1. Püschel AW, Adams RH, Betz H . Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension . Neuron . 14 . 5 . 941–8 . May 1995 . 7748561 . 10.1016/0896-6273(95)90332-1 . free .
2. Sekido Y, Bader S, Latif F, Chen JY, Duh FM, Wei MH, Albanesi JP, Lee CC, Lerman MI, Minna JD . Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns . Proceedings of the National Academy of Sciences of the United States of America . 93 . 9 . 4120–5 . April 1996 . 8633026 . 39497 . 10.1073/pnas.93.9.4120 . 1996PNAS...93.4120S . free .
3. Web site: Entrez Gene: SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B.