SELS (gene) explained

Selenoprotein S, also known as SELS, is a human gene.^[1]

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Interactions

SELS (gene) has been shown to interact with Valosin-containing protein.^{[2] [3]}

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, etal . Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening . Genomics . 23 . 1 . 42–50 . 1995 . 7829101 . 10.1006/geno.1994.1457 .
• Maruyama K . Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Bonaldo MF . Lennon G . Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hu RM, Han ZG, Song HD, etal . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–9548 . 2000 . 10931946 . 10.1073/pnas.160270997 . 16901 . 2000PNAS...97.9543H . free .
• Walder K, Kantham L, McMillan JS, etal . Tanis: a link between type 2 diabetes and inflammation? . Diabetes . 51 . 6 . 1859–1866 . 2002 . 12031974 . 10.2337/diabetes.51.6.1859 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gao Y, Walder K, Sunderland T, etal . Elevation in Tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells . Diabetes . 52 . 4 . 929–934 . 2003 . 12663463 . 10.2337/diabetes.52.4.929 . free .
• Kryukov GV, Castellano S, Novoselov SV, etal . Characterization of mammalian selenoproteomes . Science . 300 . 5624 . 1439–1443 . 2003 . 12775843 . 10.1126/science.1083516 . 2003Sci...300.1439K . 10363908 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gao Y, Feng HC, Walder K, etal . Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein . FEBS Lett. . 563 . 1–3 . 185–190 . 2004 . 15063746 . 10.1016/S0014-5793(04)00296-0 . 2004FEBSL.563..185G . 10536/DRO/DU:30002457 . 45977972 . free .
• Karlsson HK, Tsuchida H, Lake S, etal . Relationship between serum amyloid A level and Tanis/SelS mRNA expression in skeletal muscle and adipose tissue from healthy and type 2 diabetic subjects . Diabetes . 53 . 6 . 1424–1428 . 2004 . 15161744 . 10.2337/diabetes.53.6.1424 . free .
• Ye Y, Shibata Y, Yun C, etal . A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol . Nature . 429 . 6994 . 841–847 . 2004 . 15215856 . 10.1038/nature02656 . 2004Natur.429..841Y . 4317750 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Lilley BN . Ploegh HL . Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane . Proc. Natl. Acad. Sci. U.S.A. . 102 . 40 . 14296–14301 . 2006 . 16186509 . 10.1073/pnas.0505014102 . 1242303 . free .
• Ye Y, Shibata Y, Kikkert M, etal . Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane . Proc. Natl. Acad. Sci. U.S.A. . 102 . 40 . 14132–14138 . 2006 . 16186510 . 10.1073/pnas.0505006102 . 1242302 . free .
• Curran JE, Jowett JB, Elliott KS, etal . Genetic variation in selenoprotein S influences inflammatory response . Nat. Genet. . 37 . 11 . 1234–1241 . 2006 . 16227999 . 10.1038/ng1655 . 10536/DRO/DU:30006596 . 19184873 . free .
• Gao Y, Hannan NR, Wanyonyi S, etal . Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells . Cytokine . 33 . 5 . 246–251 . 2006 . 16574427 . 10.1016/j.cyto.2006.02.005 .
• Gao Y, Pagnon J, Feng HC, etal . Secretion of the glucose-regulated selenoprotein SEPS1 from hepatoma cells . Biochem. Biophys. Res. Commun. . 356 . 3 . 636–641 . 2007 . 17374524 . 10.1016/j.bbrc.2007.03.018 .
• Seiderer J, Dambacher J, Kühnlein B, etal . The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation . Tissue Antigens . 70 . 3 . 238–246 . 2007 . 17661913 . 10.1111/j.1399-0039.2007.00888.x .

Notes and References

1. Web site: Entrez Gene: SELS selenoprotein S.
2. Ye . Yihong . Shibata Yoko . Yun Chi . Ron David . Rapoport Tom A . Jun 2004 . A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol . . 429 . 6994 . 841–847 . 15215856 . 10.1038/nature02656 . 2004Natur.429..841Y . 4317750 .
3. Wang . Qiuyan . Li Lianyun . Ye Yihong . Mar 2008 . Inhibition of p97-dependent Protein Degradation by Eeyarestatin I . J. Biol. Chem. . 283 . 12 . 7445–7454 . 0021-9258. 18199748 . 10.1074/jbc.M708347200 . 2276333 . free .