SELENBP1 explained

Selenium-binding protein 1 is a protein that in humans is encoded by the SELENBP1 gene.^{[1] [2]}

This gene product belongs to the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. It has been proposed that the effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins. The exact function of this gene is not known.^[2]

Interactions

SELENBP1 has been shown to interact with USP33.^[3]

Further reading

• Kim H, Kang HJ, You KT, Kim SH, Lee KY, Kim TI, Kim C, Song SY, Kim HJ, Lee C, Kim H . 6 . Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival . Proteomics . 6 . 11 . 3466–76 . June 2006 . 16645984 . 10.1002/pmic.200500629 . 25705896 .
• Huang KC, Park DC, Ng SK, Lee JY, Ni X, Ng WC, Bandera CA, Welch WR, Berkowitz RS, Mok SC, Ng SW . 6 . Selenium binding protein 1 in ovarian cancer . International Journal of Cancer . 118 . 10 . 2433–40 . May 2006 . 16380993 . 10.1002/ijc.21671 . 10283492 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . 6 . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . September 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Miyaguchi K . Localization of selenium-binding protein at the tips of rapidly extending protrusions . Histochemistry and Cell Biology . 121 . 5 . 371–6 . May 2004 . 15108003 . 10.1007/s00418-004-0623-y . 32184041 .
• Porat A, Sagiv Y, Elazar Z . A 56-kDa selenium-binding protein participates in intra-Golgi protein transport . The Journal of Biological Chemistry . 275 . 19 . 14457–65 . May 2000 . 10799528 . 10.1074/jbc.275.19.14457 . free .
• Lanfear J, Fleming J, Walker M, Harrison P . Different patterns of regulation of the genes encoding the closely related 56 kDa selenium- and acetaminophen-binding proteins in normal tissues and during carcinogenesis . Carcinogenesis . 14 . 3 . 335–40 . March 1993 . 8453708 . 10.1093/carcin/14.3.335 .
• Czar MJ, Owens-Grillo JK, Dittmar KD, Hutchison KA, Zacharek AM, Leach KL, Deibel MR, Pratt WB . 6 . Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex . The Journal of Biological Chemistry . 269 . 15 . 11155–61 . April 1994 . 10.1016/S0021-9258(19)78104-6 . 8157642 . free .
• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin . The Journal of Infection . 24 . 3 . 317–20 . May 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .
• Bartolone JB, Birge RB, Bulera SJ, Bruno MK, Nishanian EV, Cohen SD, Khairallah EA . Purification, antibody production, and partial amino acid sequence of the 58-kDa acetaminophen-binding liver proteins . Toxicology and Applied Pharmacology . 113 . 1 . 19–29 . March 1992 . 1553752 . 10.1016/0041-008X(92)90004-C .
• Veldscholte J, Berrevoets CA, Brinkmann AO, Grootegoed JA, Mulder E . Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation . Biochemistry . 31 . 8 . 2393–9 . March 1992 . 1540595 . 10.1021/bi00123a026 .

Notes and References

1. Chang PW, Tsui SK, Liew C, Lee CC, Waye MM, Fung KP . Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein . Journal of Cellular Biochemistry . 64 . 2 . 217–24 . February 1997 . 9027582 . 10.1002/(SICI)1097-4644(199702)64:2<217::AID-JCB5>3.0.CO;2-# . 196602787 .
2. Web site: Entrez Gene: SELENBP1 selenium binding protein 1.
3. Jeong JY, Wang Y, Sytkowski AJ . Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner . Biochemical and Biophysical Research Communications . 379 . 2 . 583–8 . February 2009 . 19118533 . 10.1016/j.bbrc.2008.12.110 .