SEDLP explained

Trafficking protein particle complex subunit 2 is a protein that in humans is encoded by the TRAPPC2P1 gene.^[1]

This gene has been described as a transcribed retropseudogene (or retro-xaptonuon) based on its structure which lacks most of the introns of SEDL and the detection of transcripts from this locus. Most retropseudogenes are thought to not express protein products. A protein product could potentially be encoded by this retropseudogene that would be identical to the protein product of the SEDL gene. However, it remains unclear whether this gene encodes a protein product or is a transcribed retropseudogene.^[2]

Further reading

• Sacher M . Membrane traffic fuses with cartilage development. . FEBS Lett. . 550 . 1–3 . 1–4 . 2003 . 12935876 . 10.1016/S0014-5793(03)00854-8 . 7388750 . 2003FEBSL.550....1S .
• Gécz J, Hillman MA, Gedeon AK, etal . Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda . Genomics . 69 . 2 . 242–51 . 2001 . 11031107 . 10.1006/geno.2000.6326 .
• Ghosh AK, Majumder M, Steele R, etal . A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1 . Mol. Cell. Biol. . 21 . 2 . 655–62 . 2001 . 11134351 . 10.1128/MCB.21.2.655-662.2001 . 86643 .
• Venter JC, Adams MD, Myers EW, etal . The sequence of the human genome . Science . 291 . 5507 . 1304–51 . 2001 . 11181995 . 10.1126/science.1058040 . 2001Sci...291.1304V .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ghosh AK, Steele R, Ray RB . Modulation of human luteinizing hormone beta gene transcription by MIP-2A . J. Biol. Chem. . 278 . 26 . 24033–8 . 2003 . 12700240 . 10.1074/jbc.M211982200 . free .
• Savarirayan R, Thompson E, Gécz J . Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400) . Eur. J. Hum. Genet. . 11 . 9 . 639–42 . 2004 . 12939648 . 10.1038/sj.ejhg.5201025 . free .
• Gécz J, Shaw MA, Bellon JR, de Barros Lopes M . Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not . Gene . 320 . 137–44 . 2004 . 14597397 . 10.1016/S0378-1119(03)00819-9 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Web site: Entrez Gene: SEDLP spondyloepiphyseal dysplasia, late, pseudogene.
2. Web site: Entrez Gene: SEDLP spondyloepiphyseal dysplasia, late, pseudogene.