SEC61G explained

Protein transport protein Sec61 subunit gamma is a protein that in humans is encoded by the SEC61G gene.^{[1] [2] [3]}

Function

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[3]

Further reading

• Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL . Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction . Nature . 384 . 6608 . 432–8 . December 1996 . 8945469 . 10.1038/384432a0 . 1996Natur.384..432W . 6276718 .
• Chen Y, Le Cahérec F, Chuck SL . Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex . The Journal of Biological Chemistry . 273 . 19 . 11887–94 . May 1998 . 9565615 . 10.1074/jbc.273.19.11887 . free .
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Research . 10 . 10 . 1546–60 . October 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . November 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Research . 14 . 10B . 2136–44 . October 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Research . 34 . Database issue . D415–8 . January 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .

Notes and References

1. Hartmann E, Sommer T, Prehn S, Görlich D, Jentsch S, Rapoport TA . Evolutionary conservation of components of the protein translocation complex . Nature . 367 . 6464 . 654–7 . February 1994 . 8107851 . 10.1038/367654a0 . 1994Natur.367..654H . 4323463 .
2. Greenfield JJ, High S . The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment . Journal of Cell Science . 112 (Pt 10) . 10 . 1477–86 . May 1999 . 10.1242/jcs.112.10.1477 . 10212142 .
3. Web site: Entrez Gene: SEC61G Sec61 gamma subunit.