SEC61B explained

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.^{[1] [2]}

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.^[3]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Wiertz EJ, Tortorella D, Bogyo M, etal . Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction . Nature . 384 . 6608 . 432–8 . 1997 . 8945469 . 10.1038/384432a0 . 6276718 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Knight BC, High S . Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex . Biochem. J. . 331 . Pt 1. 161–7 . 1998 . 9512475 . 10.1042/bj3310161. 1219334 .
• Chen Y, Le Cahérec F, Chuck SL . Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex . J. Biol. Chem. . 273 . 19 . 11887–94 . 1998 . 9565615 . 10.1074/jbc.273.19.11887 . free .
• Kalies KU, Rapoport TA, Hartmann E . The β Subunit of the Sec61 Complex Facilitates Cotranslational Protein Transport and Interacts with the Signal Peptidase during Translocation . J. Cell Biol. . 141 . 4 . 887–94 . 1998 . 9585408 . 10.1083/jcb.141.4.887 . 2132780 .
• Bebök Z, Mazzochi C, King SA, etal . The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary . J. Biol. Chem. . 273 . 45 . 29873–8 . 1998 . 9792704 . 10.1074/jbc.273.45.29873 . free .
• Ingley E, Williams JH, Walker CE, etal . A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit . FEBS Lett. . 459 . 1 . 69–74 . 1999 . 10508919 . 10.1016/S0014-5793(99)01188-6 . 30948975 .
• Yamaguchi A, Hori O, Stern DM, etal . Stress-Associated Endoplasmic Reticulum Protein 1 (Serp1)/Ribosome-Associated Membrane Protein 4 (Ramp4) Stabilizes Membrane Proteins during Stress and Facilitates Subsequent Glycosylation . J. Cell Biol. . 147 . 6 . 1195–204 . 2000 . 10601334 . 10.1083/jcb.147.6.1195 . 2168098 .
• Meyer HA, Grau H, Kraft R, etal . Mammalian Sec61 is associated with Sec62 and Sec63 . J. Biol. Chem. . 275 . 19 . 14550–7 . 2000 . 10799540 . 10.1074/jbc.275.19.14550 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Humphray SJ, Oliver K, Hunt AR, etal . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Besemer J, Harant H, Wang S, etal . Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1 . Nature . 436 . 7048 . 290–3 . 2005 . 16015337 . 10.1038/nature03670 . 2005Natur.436..290B . 4431610 .
• Kim JE, Tannenbaum SR, White FM . Global phosphoproteome of HT-29 human colon adenocarcinoma cells . J. Proteome Res. . 4 . 4 . 1339–46 . 2005 . 16083285 . 10.1021/pr050048h .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Liao HJ, Carpenter G . Role of the Sec61 Translocon in EGF Receptor Trafficking to the Nucleus and Gene Expression . Mol. Biol. Cell . 18 . 3 . 1064–72 . 2007 . 17215517 . 10.1091/mbc.E06-09-0802 . 1805100 .

Notes and References

1. Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA . Evolutionary conservation of components of the protein translocation complex . Nature . 367 . 6464 . 654–7 . Mar 1994 . 8107851 . 10.1038/367654a0 . 1994Natur.367..654H . 4323463 .
2. Greenfield JJ, High S . The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment . J Cell Sci . 112 . 10. 1477–86 . Aug 1999 . 10.1242/jcs.112.10.1477 . 10212142 .
3. Web site: Entrez Gene: SEC61B Sec61 beta subunit.