SEC24D explained

Protein transport protein Sec24D is a protein that in humans is encoded by the SEC24D gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration.

Further reading

• Tang BL, Kausalya J, Low DY, etal . A family of mammalian proteins homologous to yeast Sec24p. . Biochem. Biophys. Res. Commun. . 258 . 3 . 679–84 . 1999 . 10329445 . 10.1006/bbrc.1999.0574 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway. . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Watson P, Forster R, Palmer KJ, etal . Coupling of ER exit to microtubules through direct interaction of COPII with dynactin. . Nat. Cell Biol. . 7 . 1 . 48–55 . 2005 . 15580264 . 10.1038/ncb1206 . 1592520 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Farhan H, Reiterer V, Korkhov VM, etal . Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D. . J. Biol. Chem. . 282 . 10 . 7679–89 . 2007 . 17210573 . 10.1074/jbc.M609720200 . free .

Notes and References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 5 . 5 . 277–86 . Apr 1999 . 9872452 . 10.1093/dnares/5.5.277 . free .
2. Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP . Sec24 proteins and sorting at the endoplasmic reticulum . J Biol Chem . 274 . 12 . 7833–40 . Apr 1999 . 10075675 . 10.1074/jbc.274.12.7833 . free .
3. Web site: Entrez Gene: SEC24D SEC24 related gene family, member D (S. cerevisiae).