SEC24C explained

Protein transport protein Sec24C is a protein that in humans is encoded by the SEC24C gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified.^[3]

Interactions

SEC24C has been shown to interact with SEC23A.^[4]

Further reading

• Tang BL, Kausalya J, Low DY, Lock ML, Hong W . A family of mammalian proteins homologous to yeast Sec24p . Biochem. Biophys. Res. Commun. . 258 . 3 . 679–84 . 1999 . 10329445 . 10.1006/bbrc.1999.0574 .
• Dudognon P, Maeder-Garavaglia C, Carpentier JL, Paccaud JP . Regulation of a COPII component by cytosolic O-glycosylation during mitosis . FEBS Lett. . 561 . 1–3 . 44–50 . 2004 . 15013749 . 10.1016/S0014-5793(04)00109-7 . 24041746 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Tani K, Oyama Y, Hatsuzawa K, Tagaya M . Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p . FEBS Lett. . 447 . 2–3 . 247–50 . May 1999 . 10214955 . 10.1016/S0014-5793(99)00303-8 . 41796761 .
2. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S . Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res. . 1 . 5 . 223–9 . 1994 . 7584044 . 10.1093/dnares/1.5.223 . free .
3. Web site: Entrez Gene: SEC24C SEC24 related gene family, member C (S. cerevisiae).
4. Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP . Sec24 proteins and sorting at the endoplasmic reticulum . J. Biol. Chem. . 274 . 12 . 7833–40 . Mar 1999 . 10075675 . 10.1074/jbc.274.12.7833 . free .