SEC23IP explained

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.^{[1] [2]}

COPII-coated vesicles are involved in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.^[3]

Further reading

• Li H, Xie B, Zhou Y, etal . Functional roles of p12, the fourth subunit of human DNA polymerase delta. . J. Biol. Chem. . 281 . 21 . 14748–55 . 2006 . 16510448 . 10.1074/jbc.M600322200 . free .
• Shimoi W, Ezawa I, Nakamoto K, etal . p125 is localized in endoplasmic reticulum exit sites and involved in their organization. . J. Biol. Chem. . 280 . 11 . 10141–8 . 2005 . 15623529 . 10.1074/jbc.M409673200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mizoguchi T, Nakajima K, Hatsuzawa K, etal . Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein. . Biochem. Biophys. Res. Commun. . 279 . 1 . 144–9 . 2001 . 11112430 . 10.1006/bbrc.2000.3846 .

Notes and References

1. Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M . p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins . J Biol Chem . 274 . 29 . 20505–12 . Aug 1999 . 10400679 . 10.1074/jbc.274.29.20505 . free .
2. Web site: Entrez Gene: SEC23IP SEC23 interacting protein.
3. Web site: Entrez Gene: SEC23IP SEC23 interacting protein.